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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInfluence of cyclosporin A therapy on bone healing around titanium implants: A histometric and biomechanic study in rabbitspt_BR
dc.contributor.authorSakakura, CEpt_BR
dc.contributor.authorMargonar, Rpt_BR
dc.contributor.authorHolzhausen, Mpt_BR
dc.contributor.authorNociti, FHpt_BR
dc.contributor.authorAlba, RCpt_BR
dc.contributor.authorMarcantonio, Ept_BR
unicamp.author.emailelcjojr@foar.unesp.brpt_BR
unicamp.authorUniv Sao Paulo, Sch Dent, Dept Periodontol, Araraquara, SP, Brazil UNICAMP, Sch Dent, Div Periodont, Dept Prosthodont & Periodont, Piracicaba, SP, Brazilpt_BR
dc.subjectbone regenerationpt_BR
dc.subjectcyclosporin A/adverse effectspt_BR
dc.subjectdental implantspt_BR
dc.subjectosseointegrationpt_BR
dc.subjecttitaniumpt_BR
dc.subjectwound healingpt_BR
dc.subject.wosHeart-transplantationpt_BR
dc.subject.wosMineral Metabolismpt_BR
dc.subject.wosInduced Osteopeniapt_BR
dc.subject.wosMouse Calvariapt_BR
dc.subject.wosRatpt_BR
dc.subject.wosResorptionpt_BR
dc.subject.wosInvitropt_BR
dc.subject.wosLymphocytespt_BR
dc.subject.wosWithdrawalpt_BR
dc.subject.wosTissuespt_BR
dc.description.abstractBackground: Immunosuppressive agents may induce severe changes on bone metabolism. The purpose of the present study was to evaluate the influence of the administration of cyclosporin A (CsA) on the bone tissue around titanium implants. Methods: Eighteen New Zealand rabbits were randomly divided into 2 groups of 9 each. The test group (CsA) received daily subcutaneous injection of CsA (10 mg/kg body weight) and the control group (CTL) received saline solution by the same administration route. Three days after therapy began, 2 implants (7.0 mm long and 3.75 mm in diameter) were inserted bilaterally at the region of the tibial methaphysis. After 4, 8, and 12 weeks the animals were sacrificed and biomechanical tests and histometrical procedures, consisting of the determination of the percentages of bone-implant contact and bone area within the limits of the implant threads, were performed. Results: Intergroup analysis showed that the removal torque and the percentage of bone contact with the implant surface for CsA group were significantly lower than those of the CTL group at 12 weeks (28.5 and 39.2 N cm, P = 0.01; 7.76% and 18.52%, P = 0.02, respectively). Conclusion: The data from the present study suggest that long-term administration of cyclosporin A may negatively influence bone healing around dental implants.pt
dc.relation.ispartofJournal Of Periodontologypt_BR
dc.relation.ispartofabbreviationJ. Periodont.pt_BR
dc.publisher.cityChicagopt_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Acad Periodontologypt_BR
dc.date.issued2003pt_BR
dc.date.monthofcirculationJULpt_BR
dc.identifier.citationJournal Of Periodontology. Amer Acad Periodontology, v. 74, n. 7, n. 976, n. 981, 2003.pt_BR
dc.language.isoenpt_BR
dc.description.volume74pt_BR
dc.description.issuenumber7pt_BR
dc.description.firstpage976pt_BR
dc.description.lastpage981pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESP USPpt_BR
dc.identifier.issn0022-3492pt_BR
dc.identifier.wosidWOS:000187315200005pt_BR
dc.identifier.doi10.1902/jop.2003.74.7.976pt_BR
dc.date.available2014-11-19T17:21:45Z
dc.date.available2015-11-26T18:04:44Z-
dc.date.accessioned2014-11-19T17:21:45Z
dc.date.accessioned2015-11-26T18:04:44Z-
dc.description.provenanceMade available in DSpace on 2014-11-19T17:21:45Z (GMT). No. of bitstreams: 1 WOS000187315200005.pdf: 227809 bytes, checksum: e5c1bdef51bbb71e5effadc19730f4d6 (MD5) Previous issue date: 2003en
dc.description.provenanceMade available in DSpace on 2015-11-26T18:04:44Z (GMT). No. of bitstreams: 2 WOS000187315200005.pdf: 227809 bytes, checksum: e5c1bdef51bbb71e5effadc19730f4d6 (MD5) WOS000187315200005.pdf.txt: 26304 bytes, checksum: 492d87a2db6451412bc86fe0f5702329 (MD5) Previous issue date: 2003en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60249pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/60249
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60249-
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