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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: A study on naturally infected dogspt_BR
dc.contributor.authorSantana, CCpt_BR
dc.contributor.authorVassallo, Jpt_BR
dc.contributor.authorDe Freitas, LARpt_BR
dc.contributor.authorOliveira, GGSpt_BR
dc.contributor.authorPontes-De-Carvalho, LCpt_BR
dc.contributor.authorDos-Santos, WLCpt_BR
unicamp.author.emailwluis@bahia.fiocruz.brpt_BR
unicamp.authorDos-Santos, W. L. C. Fiocruz MS, Ctr Pesquisas Goncalo Moniz, BR-40296710 Salvador, BA, Brazilpt_BR
unicamp.authorVassallo, J. Univ Estadual Campinas, Fac Ciencias Med, Campinas, SP, Brazilpt_BR
dc.subjectcanine visceral leishmaniasispt_BR
dc.subjectLeishmania chagasipt_BR
dc.subjectLeishmania infantumpt_BR
dc.subjectlymphoid tissuept_BR
dc.subjectSpleenpt_BR
dc.subject.wosCanine Leishmaniasispt_BR
dc.subject.wosDendritic Cellspt_BR
dc.subject.wosEndemic Areapt_BR
dc.subject.wosCutaneous Leishmaniasispt_BR
dc.subject.wosSkin Reactionspt_BR
dc.subject.wosPlasma-cellspt_BR
dc.subject.wosIfn-gammapt_BR
dc.subject.wosSpleenpt_BR
dc.subject.wosChagasipt_BR
dc.subject.wosBrazilpt_BR
dc.description.abstractThe aim of this study was to identify splenic immuno-inflammatory patterns associated with natural infection by Leishmania chagasi. Spleen samples were obtained from 72 stray dogs from an endemic area of visceral leishmaniasis. The animals were grouped into four categories as follows: (i) potentially resistant to visceral leishmaniasis, with a positive leishmanin skin test result, and negative splenic culture for Leishmania parasites (ii) potentially susceptible to visceral leishmaniasis, with a negative leishmanin skin test and positive splenic culture for Leishmania (iii) infected with undefined susceptibility status, with a positive leishmanin skin test and positive splenic culture for Leishmania, and (iv) noninfected, with a negative leishmanin skin test, negative splenic culture for Leishmania, and negative serology for anti-Leishmania antibodies. Histopathological analyses showed that there was a higher frequency of perisplenitis (18/25, P < 0.0001), granuloma (7/25, P = 0.0102), structural disorganization (14/25, P < 0.0001), and atrophy of the lymphoid follicles (20/25, P = 0.0036) and of the marginal zone (15/25, P = 0.0025) in the potentially susceptible group than in the other groups. The data presented here show changes in the white pulp of the spleen that are associated with naturally acquired visceral leishmaniasis.pt
dc.relation.ispartofParasite Immunologypt_BR
dc.relation.ispartofabbreviationParasite Immunol.pt_BR
dc.publisher.cityMaldenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-blackwellpt_BR
dc.date.issued2008pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationParasite Immunology. Wiley-blackwell, v. 30, n. 10, n. 515, n. 524, 2008.pt_BR
dc.language.isoenpt_BR
dc.description.volume30pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage515pt_BR
dc.description.lastpage524pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0141-9838pt_BR
dc.identifier.wosidWOS:000259087600002pt_BR
dc.identifier.doi10.1111/j.1365-3024.2008.01051.xpt_BR
dc.description.sponsorshipBrazilian Ministry of Science and Technology [7500320060, 7628720064]pt_BR
dc.description.sponsorshipRENORBIO Program [BNB 737, FINEP 3773/05]pt_BR
dc.description.sponsorshipINOVABIO Program [FINEP 381]pt_BR
dc.description.sponsorshipFAPESB [APR0434/2005]pt_BR
dc.description.sponsordocumentnumberBrazilian Ministry of Science and Technology [7500320060, 7628720064]pt
dc.description.sponsordocumentnumberRENORBIO Program [BNB 737, FINEP 3773/05]pt
dc.description.sponsordocumentnumberINOVABIO Program [FINEP 381]pt
dc.description.sponsordocumentnumberFAPESB [APR0434/2005]pt
dc.date.available2014-07-30T14:33:26Z
dc.date.available2015-11-26T17:47:58Z-
dc.date.accessioned2014-07-30T14:33:26Z
dc.date.accessioned2015-11-26T17:47:58Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60154
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60154-
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