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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleInduction of apoptosis in Vero cells by Aeromonas veronii biovar sobria vacuolating cytotoxic factorpt_BR
dc.contributor.authorMartins, LMpt_BR
dc.contributor.authorCatani, CFpt_BR
dc.contributor.authorFalcon, RMpt_BR
dc.contributor.authorCarbonell, GVpt_BR
dc.contributor.authorAzzoni, AApt_BR
dc.contributor.authorYano, Tpt_BR
unicamp.author.emailtyano@unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Inst Biol, Dept Microbiol & Imunol, Ctr Biol Mol & Genet, BR-13083862 Campinas, SP, Brazil Inst Pedro Kouri, Dept Microbiol, Havana, Cuba Inst Adolfo Lutz Registro, Bacteriol Clin, Campinas, SP, Brazilpt_BR
dc.subjectAeromonas veronii bv. sobriapt_BR
dc.subjectvacuolating cytotoxic factorpt_BR
dc.subjectpurificationpt_BR
dc.subjectserine proteasept_BR
dc.subjectapoptosispt_BR
dc.subjectVero cellspt_BR
dc.subject.wosVibrio-choleraept_BR
dc.subject.wosSerine-proteasept_BR
dc.subject.wosEntero-toxinpt_BR
dc.subject.wosHydrophilapt_BR
dc.subject.wosHemolysinpt_BR
dc.subject.wosPurificationpt_BR
dc.subject.wosMetalloproteasept_BR
dc.subject.wosLethalpt_BR
dc.subject.wosStrainpt_BR
dc.description.abstractRecently, a cytotoxin named vacuolating cytotoxic factor (VCF) in Aeromonas sobria and Aeromonas veronii biovar sobria was described. We have now purified this factor using ion metallic affinity chromatography. The VCF is a nonhemolytic enterotoxin that acts as a serine protease. The toxin can be partially neutralized by serum antiaerolysin and it induced not only cytoplasmatic vacuole formation, but also mitochondrial disorders that must be signaling the apoptotic pathways, leading to Vero (African green monkey kidney) cell death. These results suggest that the VCF is a virulence factor of these bacteria, participating in the processes of human disease provoked by preformed toxins in food and infection.pt
dc.relation.ispartofFems Immunology And Medical Microbiologypt_BR
dc.relation.ispartofabbreviationFEMS Immunol. Med. Microbiol.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherBlackwell Publishingpt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationMARpt_BR
dc.identifier.citationFems Immunology And Medical Microbiology. Blackwell Publishing, v. 49, n. 2, n. 197, n. 204, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume49pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage197pt_BR
dc.description.lastpage204pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0928-8244pt_BR
dc.identifier.wosidWOS:000244228300004pt_BR
dc.identifier.doi10.1111/j.1574-695X.2006.00176.xpt_BR
dc.date.available2014-11-19T07:18:54Z
dc.date.available2015-11-26T17:59:47Z-
dc.date.accessioned2014-11-19T07:18:54Z
dc.date.accessioned2015-11-26T17:59:47Z-
dc.description.provenanceMade available in DSpace on 2014-11-19T07:18:54Z (GMT). No. of bitstreams: 1 WOS000244228300004.pdf: 1840119 bytes, checksum: 47431dadec263c7f1c42aef7742dd9af (MD5) Previous issue date: 2007en
dc.description.provenanceMade available in DSpace on 2015-11-26T17:59:47Z (GMT). No. of bitstreams: 2 WOS000244228300004.pdf: 1840119 bytes, checksum: 47431dadec263c7f1c42aef7742dd9af (MD5) WOS000244228300004.pdf.txt: 26497 bytes, checksum: ab2cc88837c37a9707db74bec025d226 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60100pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/60100
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60100-
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