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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleIncidence and antimicrobial susceptibility of Porphyromonas gingivalis isolated from mixed endodontic infectionspt_BR
dc.contributor.authorJacinto, RCpt_BR
dc.contributor.authorGomes, BPFApt_BR
dc.contributor.authorShah, HNpt_BR
dc.contributor.authorFerraz, CCpt_BR
dc.contributor.authorZaia, AApt_BR
dc.contributor.authorSouza, FJpt_BR
unicamp.authorUniv Estadual Campinas, FOP, Endodont Dept, Piracicaba Dent Sch, BR-13414018 Piracicaba, SP, Brazil Hlth Protect Agcy, NCTC MISU, London, Englandpt_BR
dc.subjectanaerobic bacteriapt_BR
dc.subjectantimicrobial susceptibilitypt_BR
dc.subjectendodontic infectionpt_BR
dc.subjectPorphyromonas gingivalispt_BR
dc.subject.wosBlack-pigmented Bacteroidespt_BR
dc.subject.wosAdvanced Periodontitis Patientspt_BR
dc.subject.wosGram-negative Anaerobespt_BR
dc.subject.wosRoot-canal Infectionspt_BR
dc.subject.wosSuccess Ratept_BR
dc.description.abstractAim To investigate the prevalence of Porphyromonas gingivalis in root canals of infected teeth with periapical abscesses and to investigate the antimicrobial susceptibility of this species to some frequently prescribed antibiotics. Methodology Samples were obtained from 70 root canals of abscessed teeth. Microbial sampling, isolation and bacterial identification were accomplished using appropriate culture methods for anaerobic species. The antimicrobial susceptibility of the 20 strains of P. gingivalis isolated was determined by using the E-test. The antimicrobial agents tested were amoxicillin, amoxicillin + clavulanate, azythromycin, benzylpenicillin, cephaclor, clindamycin, erythromycin, metronidazole and tetracycline. Results A total of 352 individual strains, belonging to 69 different species, were isolated. Eighty three percent of the strains were strict anaerobes and 47.5% of the isolated bacteria were Gram-negative. Porphyromonas gingivalis was found in 20 root canals and was most frequently found in symptomatic cases. Statistically, the presence of P. gingivalis was related to purulent exudates and pain on palpation (both P < 0.05). All P. gingivalis strains were sensitive to amoxicillin, amoxicillin + clavulanate, cephaclor, clindamycin, benzylpenicyllin, metronidazole and tetracycline. The lowest range of minimum inhibitory concentration (MIC) (0.026-0.125 mu g mL(-1)) was observed against amoxicillin + clavulanate and clindamycin. The lowest MIC 90 was observed against clindamycin (0.064 mu g mL(-1)). One strain was resistant to erythromycin and eight strains were resistant to azythromycin. Conclusion Porphyromonas gingivalis pathogen is isolated with frequency from root canals of infected teeth with periapical abscesses. Amoxicillin, as well as amoxicillin-clavulanic acid and benzylpenicillin were effective against P.
dc.relation.ispartofInternational Endodontic Journalpt_BR
dc.relation.ispartofabbreviationInt. Endod. J.pt_BR
dc.publisherBlackwell Publishingpt_BR
dc.identifier.citationInternational Endodontic Journal. Blackwell Publishing, v. 39, n. 1, n. 62, n. 70, 2006.pt_BR
dc.sourceWeb of Sciencept_BR
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