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Type: Artigo de periódico
Title: Platelet associated IgG may be related with thrombocytopenia in patients with myelodysplastic syndromes
Author: Gilli, SCO
Medina, SD
de Castro, V
Fernandes, LGR
Saad, STO
Abstract: Thrombocytopenia is common in patients with myelodysplastic syndromes (MDS) and immune destruction of platelets could be an important factor for its occurrence. We prospectively analyzed platelet-associated IgG (PAIgG) through platelet immunofluorescence test (PIFT), mean platelet volume (MPV), platelet size deviation width (PDW) and glycocalicin index (GCI) of 54 patients with MDS, classified according to the International Prognostic Scoring System (IPSS). Thrombocytopenia (platelet count < 100 x 10(9)/L) was correlated with a higher amount of PAIgG, significantly higher MPV and increased GCI. In addition, worse prognosis IPSS groups were associated with a higher positivity of PIFT, which could be indicative of advanced disease. (C) 2011 Elsevier Ltd. All rights reserved.
Subject: Myelodysplastic syndrome
Platelet indices
Glycocalicin index
Country: Inglaterra
Editor: Pergamon-elsevier Science Ltd
Citation: Leukemia Research. Pergamon-elsevier Science Ltd, v. 36, n. 5, n. 554, n. 559, 2012.
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2011.10.003
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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