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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePlasmacytoid dendritic cells are increased in cerebrospinal fluid of untreated patients during multiple sclerosis relapsept_BR
dc.contributor.authorLonghini, ALFpt_BR
dc.contributor.authorvon Glehn, Fpt_BR
dc.contributor.authorBrandao, COpt_BR
dc.contributor.authorde Paula, RFOpt_BR
dc.contributor.authorPradella, Fpt_BR
dc.contributor.authorMoraes, ASpt_BR
dc.contributor.authorFarias, ASpt_BR
dc.contributor.authorOliveira, ECpt_BR
dc.contributor.authorQuispe-Cabanillas, JGpt_BR
dc.contributor.authorAbreu, CHpt_BR
dc.contributor.authorDamasceno, Apt_BR
dc.contributor.authorDamasceno, BPpt_BR
dc.contributor.authorBalashov, KEpt_BR
dc.contributor.authorSantos, LMBpt_BR
unicamp.authorLonghini, Ana Leda F. von Glehn, Felipe Brandao, Carlos Otavio de Paula, Rosemeire F. O. Pradella, Fernando Moraes, Adriel S. Farias, Alessandro S. Oliveira, Elaine C. Quispe-Cabanillas, Juan G. Abreu, Cassiana Horta Santos, Leonilda M. B. Univ Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, Neuroimmunol Unit, Campinas, SP, Brazilpt_BR
unicamp.authorvon Glehn, Felipe Abreu, Cassiana Horta Damasceno, Alfredo Damasceno, Benito P. Univ Estadual Campinas, Dept Neurol, Campinas, SP, Brazilpt_BR
unicamp.authorOliveira, Elaine C. FATEC Sorocaba, Sorocaba, SP, Brazilpt_BR
unicamp.authorBalashov, Konstantin E. Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, New Brunswick, NJ USApt_BR
dc.description.abstractThe plasmacytoid dendritic cells (pDCs) express a high level of Toll-like receptor 9 (TLR-9), which recognizes viral DNA. Activated via TLR-9, pDCs also secrete large amounts of type I interferon which are involved either in stimulation or down regulation of immune response in multiple sclerosis (MS). In the present study, we determinate pDCs levels by flow cytometry in Cerebrospinal Fluid (CSF) and Peripheral Blood from MS patients in relapsing and in remitting phases of the disease, comparing with other non-inflammatory diseases (OND). We provide evidence that MS patients in relapse without any treatment have a significantly (p < 0.01) higher percentage of pDCs in CSF than do patients in remission or those with OND. No change in the percentage of pDCs was observed in the peripheral blood of any of these patients. The increase of pDCs in central nervous system during relapse may be explained either by a virus infection or a down regulatory
dc.relation.ispartofJournal Of Neuroinflammationpt_BR
dc.relation.ispartofabbreviationJ. Neuroinflamm.pt_BR
dc.publisherBiomed Central Ltdpt_BR
dc.identifier.citationJournal Of Neuroinflammation. Biomed Central Ltd, v. 8, 2011.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.provenanceMade available in DSpace on 2014-07-30T14:32:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2011en
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