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Type: Artigo de periódico
Title: Phosphorylimidazole Derivatives: Potentially Biosignaling Molecules
Author: Orth, ES
Wanderlind, EH
Medeiros, M
Oliveira, PSM
Vaz, BG
Eberlin, MN
Kirby, AJ
Nome, F
Abstract: The phosphorylation of imidazole by two activated phosphate diesters and a triester gives phosphorylimidazole derivatives that are stable enough in aqueous solution to be observed and identified by ESI-MS/MS and NMR Half-lives ranging from hours to days (in the case of the monoethyl ester) show that it is possible to design molecules with variable half-lives with potential to be used for biological intervention experiments as possible inhibitors of biosignaling processes or as haptens for the generation of antibodies.
Country: EUA
Editor: Amer Chemical Soc
Citation: Journal Of Organic Chemistry. Amer Chemical Soc, v. 76, n. 19, n. 8003, n. 8008, 2011.
Rights: fechado
Identifier DOI: 10.1021/jo2017394
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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