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Type: Artigo de periódico
Title: Peri-Infarct Zone Characterized by Cardiac Magnetic Resonance Imaging is Directly Associated with the Inflammatory Activity During Acute Phase Myocardial Infarction
Author: Silva, JCQE
Coelho, OR
Andrade, JM
Quinaglia, T
Modolo, RGP
Almeida, BO
van der Geest, RJ
Jerosch-Herold, M
Coelho, OR
Sposito, AC
Abstract: Enhanced systemic inflammatory activity (SIA) during myocardial infarction (MI) and the extent of the peri-infarct zone characterized by cardiac magnetic resonance imaging (CMRi) are both associated with increased risk of life-threatening arrhythmias and sudden cardiac death. The present study investigated the existence of association between these two phenomena in 98 patients (55 +/- 10 years) with ST segment elevation MI. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor (TNF) were measured on admission (D1) and on the fifth day post-MI (D5). CMRi was performed 2 weeks after MI to quantify peri-infarct zone (PIZ). Between D1 and D5, the increase in CRP (6.0 vs. 5.6 times; p = 0.02), IL-2 (3.6 vs. 3.4 times; p = 0.04) and tumor necrosis factor type alpha (TNF-alpha; 4.6 vs. 3.9 times; p = 0.001) were higher in patients with PIZ above the median than in the counterparts. PIZ was correlated with CRP-D5 (r = 0.69), delta-CRP (r = 0.7), IL-2-D5 (r = 0.5), delta-IL-2 (r = 0.6), TNF-alpha (r = 0.5), delta-TNF-alpha (r = 0.4; p = 0.0001). Enhanced activation of SIA during the acute phase of MI is directly related with generation of PIZ.
Subject: myocardial infarction
magnetic resonance imaging
peri-infarct zone
Country: EUA
Editor: Springer/plenum Publishers
Citation: Inflammation. Springer/plenum Publishers, v. 37, n. 3, n. 678, n. 685, 2014.
Rights: fechado
Identifier DOI: 10.1007/s10753-013-9784-y
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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