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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePatterns of Demineralization and Dentin Reactions in Radiation-Related Cariespt_BR
dc.contributor.authorSilva, ARSpt_BR
dc.contributor.authorAlves, FApt_BR
dc.contributor.authorAntunes, Apt_BR
dc.contributor.authorGoes, MFpt_BR
dc.contributor.authorLopes, MApt_BR
unicamp.authorLopes, M. A. Univ Estadual Campinas, Dept Oral Diag, Semiol Sect, Piracicaba Dent Sch, BR-13414900 Piracicaba, SP, Brazilpt_BR
unicamp.authorAntunes, A. Goes, M. F. Univ Estadual Campinas, Dept Restorat Dent, Piracicaba Dent Sch, BR-13414900 Piracicaba, SP, Brazilpt_BR
unicamp.authorAlves, F. A. Canc Hosp AC Camargo, Dept Stomatol, Sao Paulo, Brazilpt_BR
dc.subjectDental cariespt_BR
dc.subjectPolarized light microscopypt_BR
dc.subjectRadiation cariespt_BR
dc.subjectRadiation-related cariespt_BR
dc.subjectScanning electron microscopypt_BR
dc.subject.wosSitu-induced Demineralizationpt_BR
dc.subject.wosBackscattered Electron Imagept_BR
dc.subject.wosNonirradiated Human Dentinpt_BR
dc.description.abstractRadiation-related caries is a unique form of rampant decay and is a complication of head and neck radiotherapy that frequently causes generalized dental destruction and impairs quality of life in cancer patients. The aim of this study was to investigate the patterns of demineralization of caries in irradiated patients and to establish whether direct radiogenic damage to the dentition might be important in the progression of radiation-related caries. Teeth from patients who had concluded radiotherapy were examined histologically by polarized light microscopy, and the ultrastructure was examined by scanning backscattered electron microscopy. Cervical caries and incisal caries, a very unusual sort of lesion, were widely detected. Additionally, diffuse brown discoloration of the smooth surface of enamel was frequently observed. Polarized light microscopy suggested that these areas were incipient caries. Evidence of normal odontoblast function was observed in the detection of reactionary dentin and intratubular dentin deposition. In conclusion, radiation-related caries seems to have the same morphological and demineralization pattern as ordinary caries, with the presence of demineralized dentin, a translucent zone, dentin dead tracts, reactionary dentin and intratubular dentin deposition. Based on these findings, direct radiogenic destruction of the teeth seems to be not essential to the microscopic progression of radiation-related caries. Copyright (C) 2009 S. Karger AG, Baselpt
dc.relation.ispartofCaries Researchpt_BR
dc.relation.ispartofabbreviationCaries Res.pt_BR
dc.identifier.citationCaries Research. Karger, v. 43, n. 1, n. 43, n. 49, 2009.pt_BR
dc.sourceWeb of Sciencept_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipOral Pathology Area, Piracicaba Dental Schoolpt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberCNPq [131654/2006-3]pt
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