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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePattern of cytokine secretion by peripheral blood cells of patients with multiple sclerosis in Brazilpt_BR
dc.contributor.authorda Costa, PMpt_BR
dc.contributor.authorYasuda, CLpt_BR
dc.contributor.authorScagliusi, SMpt_BR
dc.contributor.authorDiaz-Bardales, BMpt_BR
dc.contributor.authorMaciel, Ept_BR
dc.contributor.authorDamasceno, BPpt_BR
dc.contributor.authorBlotta, MHSLpt_BR
dc.contributor.authorTilbery, CPpt_BR
dc.contributor.authorSantos, LMBpt_BR
unicamp.authorUNICAMP, Inst Biol, Dept Microbiol & Immunol, Campinas, SP, Brazil UNICAMP, Sch Med, Dept Neurol, Campinas, SP, Brazil UNICAMP, Sch Med, Dept Clin Pathol, Campinas, SP, Brazil Sch Med, Dept Neurol, Santa Casa De Sao Paulo, Brazilpt_BR
dc.subjectcytokinespt_BR
dc.subjectmyelin basic proteinpt_BR
dc.subjectautoimmunitypt_BR
dc.subject.wosMyelin Basic-proteinpt_BR
dc.subject.wosTumor-necrosis-factorpt_BR
dc.subject.wosExperimental Autoimmune Encephalomyelitispt_BR
dc.subject.wosExperimental Allergic Encephalomyelitispt_BR
dc.subject.wosMessenger-rna Expressionpt_BR
dc.subject.wosCentral-nervous-systempt_BR
dc.subject.wosTgf-betapt_BR
dc.subject.wosT-cellspt_BR
dc.subject.wosInterferon-gammapt_BR
dc.subject.wosOral Tolerancept_BR
dc.description.abstractAutoimmune T cells play a key role as regulators and effecters of organ-specific autoimmune disease. In multiple sclerosis (MS), activated T cells specific for myelin components produce a plethora of inflammatory cytokines and mediators that contribute to myelin damage. The production of proinflammatory and regulatory cytokines by peripheral blood cells from patients with active and stable MS and healthy controls were examined The results show that TNF alpha production was somewhat elevated in active MS with no significant increase in the level IFN gamma, whereas in the chronic phase the anti-inflammatory cytokines IL-10 and TGF-beta increased, accompanied by a reduction in IFN gamma when stimulated by myelin basic protein.pt
dc.relation.ispartofMultiple Sclerosispt_BR
dc.relation.ispartofabbreviationMult. Scler.pt_BR
dc.publisher.cityBasingstokept_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherNature Publishing Grouppt_BR
dc.date.issued2000pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationMultiple Sclerosis. Nature Publishing Group, v. 6, n. 5, n. 293, n. 299, 2000.pt_BR
dc.language.isoenpt_BR
dc.description.volume6pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage293pt_BR
dc.description.lastpage299pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1352-4585pt_BR
dc.identifier.wosidWOS:000089837700001pt_BR
dc.identifier.doi10.1177/135245850000600501pt_BR
dc.date.available2014-12-02T16:28:03Z
dc.date.available2015-11-26T16:35:47Z-
dc.date.accessioned2014-12-02T16:28:03Z
dc.date.accessioned2015-11-26T16:35:47Z-
dc.description.provenanceMade available in DSpace on 2014-12-02T16:28:03Z (GMT). No. of bitstreams: 1 WOS000089837700001.pdf: 194989 bytes, checksum: 5b71b939e24afd338001d92577d3be1c (MD5) Previous issue date: 2000en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:35:47Z (GMT). No. of bitstreams: 2 WOS000089837700001.pdf: 194989 bytes, checksum: 5b71b939e24afd338001d92577d3be1c (MD5) WOS000089837700001.pdf.txt: 32476 bytes, checksum: aac54b81dd3788d808384010e25f22ef (MD5) Previous issue date: 2000en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59156pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/59156
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59156-
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