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Type: Artigo de periódico
Title: Quantitative assessment of human erythrocyte membrane solubilization by Triton X-100
Author: Prete, PSC
Malheiros, SVP
Meirelles, NC
de Paula, E
Abstract: We report here a quantitative analysis of the interaction of the non-ionic surfactant Triton X-100 with human erythrocyte membranes. By applying a classical treatment for the interpretation of the action of surface active compounds to the hemolytic curves, we could calculate parameters such as R-e-the effective surfactant/lipid molar ratio for erythrocyte membrane saturation (R-e(sat)) and total lysis (R-e(sol))-and K-b, the binding constant of Triton X-100 to human erythrocyte membranes. The K-b (5900 M-1) and R-e (1.58 and 2.14) values presented here are in good agreement with literature data for Triton X-100 solubilization of model phospholipid membranes. (C) 2002 Elsevier Science B.V. All rights reserved.
Subject: erythrocyte
Triton X-100
Country: Holanda
Editor: Elsevier Science Bv
Citation: Biophysical Chemistry. Elsevier Science Bv, v. 97, n. 1, n. 1, n. 5, 2002.
Rights: fechado
Identifier DOI: 10.1016/S0301-4622(02)00043-1
Date Issue: 2002
Appears in Collections:Unicamp - Artigos e Outros Documentos

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