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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleQuantification of Endotoxins in Infected Root Canals and Acute Apical Abscess Exudates: Monitoring the Effectiveness of Root Canal Procedures in the Reduction of Endotoxinspt_BR
dc.contributor.authorSousa, ELRpt_BR
dc.contributor.authorMartinho, FCpt_BR
dc.contributor.authorNascimento, GGpt_BR
dc.contributor.authorLeite, FRMpt_BR
dc.contributor.authorGomes, BPFApt_BR
unicamp.authorSousa, Ezilmara L. R. Nascimento, Gustavo G. Leite, Fabio R. M. Univ Fed Pelotas, Sch Dent, Endodont Div, Dept Semiol & Clin, Pelotas, RS, Brazilpt_BR
unicamp.authorSousa, Ezilmara L. R. Martinho, Frederico C. Gomes, Brenda P. F. A. State Univ Campinas UNICAMP, Dept Restorat Dent, Piracicaba Dent Sch, Endodont Div, BR-13414018 Piracicaba, SP, Brazilpt_BR
unicamp.authorMartinho, Frederico C. State Univ Sao Paulo UNESP, Sao Jose dos Campos Dent Sch, Endodont Div, Dept Restorat Dent, Sao Paulo, Brazilpt_BR
dc.subjectchemomechanical preparationpt_BR
dc.subjectintracanal medicamentpt_BR
dc.subject.wosCalcium Hydroxidept_BR
dc.subject.wosEndodontic Infectionspt_BR
dc.subject.wosChemomechanical Preparationpt_BR
dc.subject.wosCultivable Bacteriapt_BR
dc.subject.wosPeriapical Lesionpt_BR
dc.description.abstractIntroduction: This clinical study was conducted to measure the endotoxin levels in infected root canals (RCs) and exudates related to acute apical abscesses (AAAs). In addition, the effectiveness of RC procedures in reducing the endotoxin levels in RCs was monitored. Methods: Paired samples of infected RCs and exudates from AAAs were collected from 10 subjects by using paper points. RCs samples were collected before (RCS1) and after chemomechanical preparation (CMP) (RCS2), after 17% EDTA (RCS3), and after 30 days of intracanal medication (Ca[OH](2) + chlorhexidine) (RCS4). A turbidimetric kinetic limulus amebocyte lysate assay was used for the measurement of endotoxins. Results: Endotoxins were detected in 100% of the baseline samples of AAAs and RCs (RCS1) with median values of 175 EU/mL and 41.5 EU/mL, respectively (P < .05). After CMP (RCS2), endotoxins were reduced to a median value of 0.54 EU/mL (P < .05). Subsequent irrigation with EDTA (RCS3) failed to present a significant effectiveness in reducing the endotoxin levels (median = 0.37 EU/mL) (P = .07). However, intracanal medication for 30 days (RCS4) reduced endotoxins to median values of 0.03 EU/mL (P < .01). Conclusions: The present study revealed a strong association between the high levels of endotoxins found in AAAs and RCs collected from the same tooth. Moreover, the effectiveness of CMP in reducing the endotoxin levels from RCs in acute endodontic infection was improved by the use of RC
dc.relation.ispartofJournal Of Endodonticspt_BR
dc.relation.ispartofabbreviationJ. Endod.pt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisherElsevier Science Incpt_BR
dc.identifier.citationJournal Of Endodontics. Elsevier Science Inc, v. 40, n. 2, n. 177, n. 181, 2014.pt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUNESP USPpt_BR
dc.description.sponsorshipBrazilian agencies: PAPESP [10/17877-4, 10/19136-1, 11/09047-4]pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsordocumentnumberBrazilian agencies: PAPESP [10/17877-4, 10/19136-1, 11/09047-4]pt
dc.description.sponsordocumentnumberCNPq [302575/2009-0, 150557/2011-6]pt
dc.description.provenanceMade available in DSpace on 2014-07-30T14:18:56Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:42:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
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