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Type: Artigo de periódico
Title: Purification of n-boc-Rolipram racemate on chiral stationary phase using simulated moving bed chromatography under linear conditions
Author: Goncalves, CV
Carpes, MJS
Correia, CRD
Santana, CC
Abstract: Chiral stationary phases (CSPs) associated with simulated moving bed (SMB) technology have shown good performance in the purification of racemates. Rolipram, (+/-)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)-pyrrolidin-2-one), is an antidepressant with significant pharmacological properties. The aim of this work was to purify the n-boc-Rolipram racemate (Rolipram intermediate) on cellulose tris(3,5-dimethylphenylcarbamate) CSP coated on silica by simulated moving bed (SMB) continuous chromatography. The experiments were carried out under diluted conditions. Henry's constants were determined and the system revealed selectivity close to 1.26. Purity and enantiomeric excess of the extract and raffinate streams were evaluated and discussed. Performance parameters of the studied system were determined also. Results showed reasonable performance of the SMB unit to separate the n-boc-Rolipram enantiomers. (c) 2008 Elsevier B.V. All rights reserved.
Subject: n-boc-Rolipram
simulated moving bed
chiral system
Country: Suíça
Editor: Elsevier Science Sa
Citation: Biochemical Engineering Journal. Elsevier Science Sa, v. 40, n. 3, n. 526, n. 536, 2008.
Rights: fechado
Identifier DOI: 10.1016/j.bej.2008.02.008
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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