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http://repositorio.unicamp.br/jspui/handle/REPOSIP/58409
Type: | Artigo de periódico |
Title: | PTK2 and PTPN11 expression in myelodysplastic syndromes |
Author: | Lazarini, M Machado-Neto, JA Archangelo, LF Mendes-Silva, BF Bigarella, CL Traina, F Saad, STO |
Abstract: | OBJECTIVE: The aim of this study was to evaluate the expression of protein tyrosine kinase 2 and protein tyrosine phosphatase non-receptor type 11, which respectively encode focal adhesion kinase protein and src homology 2 domain-containing protein-tyrosine phosphatase 2, in hematopoietic cells from patients with myelodysplastic syndromes. METHODS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions were analyzed by quantitative polymerase chain reaction in bone marrow cells from patients with myelodysplastic syndromes and healthy donors. RESULTS: Protein tyrosine kinase 2 and tyrosine phosphatase non-receptor type 11 expressions did not significantly differ between normal cells and myelodysplastic cells. CONCLUSIONS: Our data suggest that despite the relevance of focal adhesion kinase and src homology 2 domaincontaining protein-tyrosine phosphatase 2 in hematopoietic disorders, their mRNA expression do not significantly differ between total bone marrow cells from patients with myelodysplastic syndromes and healthy donors. |
Subject: | Myelodysplastic Syndromes PTPN11 PTK2 FAK SHP2 |
Country: | Brasil |
Editor: | Hospital Clinicas, Univ Sao Paulo |
Citation: | Clinics. Hospital Clinicas, Univ Sao Paulo, v. 68, n. 10, n. 1371, n. 1375, 2013. |
Rights: | aberto |
Identifier DOI: | 10.6061/clinics/2013(10)13 |
Date Issue: | 2013 |
Appears in Collections: | Unicamp - Artigos e Outros Documentos |
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