Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/58377
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePSA-nadir at 1 year as a sound contemporary prognostic factor for low-dose-rate iodine-125 seeds brachytherapypt_BR
dc.contributor.authorReis, LOpt_BR
dc.contributor.authorSanches, BCFpt_BR
dc.contributor.authorZani, ELpt_BR
dc.contributor.authorCastilho, LNpt_BR
dc.contributor.authorMonti, CRpt_BR
unicamp.author.emailreisleo.l@gmail.compt_BR
unicamp.authorReis, Leonardo Oliveira Monti, Carlos Roberto Pontifical Catholic Univ Campinas PUC Campinas, Fac Med Urol, Ctr Life Sci, Campinas, SP, Brazilpt_BR
unicamp.authorReis, Leonardo Oliveira Framil Sanches, Brunno Cezar Zani, Emerson Luis Univ Campinas Unicamp, Div Urol, Dept Surg, Sch Med Sci, BR-13083887 Campinas, SP, Brazilpt_BR
unicamp.authorReis, Leonardo Oliveira Castilho, Lisias Nogueira Monti, Carlos Roberto Radium Inst, Campinas, SP, Brazilpt_BR
dc.subjectPrognosispt_BR
dc.subjectSurvivalpt_BR
dc.subjectAgept_BR
dc.subjectRadiotherapypt_BR
dc.subjectProstatept_BR
dc.subjectOutcomept_BR
dc.subjectMarkerpt_BR
dc.subjectGleason score upgradingpt_BR
dc.subject.wosLocalized Prostate-cancerpt_BR
dc.subject.wosPermanent Interstitial Brachytherapypt_BR
dc.subject.wosBiochemical Failurept_BR
dc.subject.wosOutcomespt_BR
dc.subject.wosImplantationpt_BR
dc.subject.wosMenpt_BR
dc.subject.wosAdenocarcinomapt_BR
dc.subject.wosRadiotherapypt_BR
dc.description.abstractTo identify predictors of outcomes in patients with localized prostate cancer treated with iodine-125 brachytherapy in a longitudinal uncontrolled study. Between 2000 and 2011, 560 histologically confirmed patients were treated with brachytherapy of whom 305 with a parts per thousand yen24-month follow-up and localized tumor were evaluated after exclusion of those locally advanced and under androgen ablation. Patients' mean age was 63.93 years (44-88), mean pretreatment prostate-specific antigen (PSA) was 6.34 ng/mL (0.67-33.09), overall median follow-up was 75.35 months (24-158.37), biochemical recurrence occurred in 17 patients (5.57 %), cancer-specific survival was 100 %, and overall survival was 98.03 %. At multivariate analyses, only PSA-nadir at 1 year and age were related to disease-free survival: To each unit of PSA-nadir, the risk increases 87.3 %-OR 1.87 (p < 0.001; 95 % CI 1.31-2.67), and risk was 4.7 times higher for those under 50 years (vs. > 70)-OR 4.69 (p = 0.04; 95 % CI 1.39-18.47). Best cutoff for PSA-nadir at one year was 0.285 (AUC = 0.78; p < 0.001; 95 % CI 0.68-0.89). Kaplan-Meier analysis confirmed PSA-nadir (p < 0.001) as prognostic, while D'Amico's classification failed (p = 0.24). No grade 3 or 4 complication was reported, and only 31.4 % of patients had grade 2 urinary or rectal toxicity. PSA bounce a parts per thousand yen0.4 ng/mL occurred in 18.4 % with no impact on biochemical recurrence. Half (50.49 %) of patients in the scenario of localized prostate cancer treated with iodine-125 brachytherapy reach PSA-nadir at 1 year < 0.285, recognized as a key independent prognostic factor. [Receiver Operating Characteristic curve analysis for PSA-nadir at 1 year].pt
dc.relation.ispartofWorld Journal Of Urologypt_BR
dc.relation.ispartofabbreviationWorld J. Urol.pt_BR
dc.publisher.cityNew Yorkpt_BR
dc.publisher.countryEUApt_BR
dc.publisherSpringerpt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationJUNpt_BR
dc.identifier.citationWorld Journal Of Urology. Springer, v. 32, n. 3, n. 753, n. 759, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume32pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage753pt_BR
dc.description.lastpage759pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0pt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0724-4983pt_BR
dc.identifier.eissn1433-8726pt_BR
dc.identifier.wosidWOS:000336405800025pt_BR
dc.identifier.doi10.1007/s00345-013-1148-6pt_BR
dc.description.sponsorshipInstituto do Radium de Campinas (IRC), Campinas, SP, Brazilpt_BR
dc.date.available2014-07-30T14:18:32Z
dc.date.available2015-11-26T16:47:03Z-
dc.date.accessioned2014-07-30T14:18:32Z
dc.date.accessioned2015-11-26T16:47:03Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:18:32Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:47:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58377
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58377-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.