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Type: Artigo de periódico
Title: Protocol for volumetric segmentation of medial temporal structures using high-resolution 3-D magnetic resonance imaging
Author: Bonilha, L
Kobayashi, E
Cendes, F
Li, LM
Abstract: Quantitative analysis of brain structures in normal subjects and in different neurological conditions can be carried out in vivo through magnetic resonance imaging (MRI) volumetric studies. The use of high-resolution MRI combined with image post-processing that allows simultaneous multiplanar view may facilitate volumetric segmentation of temporal lobe structures. We define a protocol for volumetric studies of medial temporal lobe structures using high-resolution MR images and we studied 30 healthy subjects (19 women; mean age, 33 years; age range, 21-55 years). Images underwent field non-homogeneity correction and linear stereotaxic transformation into a standard space. Structures of interest comprised temporopolar, entorhinal, perirhinal, parahippocampal cortices, hippocampus, and the amygdala. Segmentation was carried out with multiplanar assessment. There was no statistically significant left/right-sided asymmetry concerning any structure analyzed. Neither gender nor age influenced the volumes obtained. The coefficient of repeatability showed no significant difference of intra- and interobserver measurements. Imaging post-processing and simultaneous multiplanar view of high-resolution MRI facilitates volumetric assessment of the medial portion of the temporal lobe with strict adherence to anatomic landmarks. This protocol shows no significant inter- and intraobserver variations and thus is reliable for longitudinal studies. (C) 2004 Wiley-Liss, Inc.
Subject: magnetic resonance image
temporal lobe
parahippocampal gyrus
volumetric analysis
Country: EUA
Editor: Wiley-liss
Citation: Human Brain Mapping. Wiley-liss, v. 22, n. 2, n. 145, n. 154, 2004.
Rights: fechado
Identifier DOI: 10.1002/hbm.20023
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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