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|Type:||Artigo de periódico|
|Title:||Protective effect of bovine milk whey protein concentrate on the ulcerative lesions caused by subcutaneous administration of indomethacin|
|Abstract:||The protective effect of a whey protein concentrate (WPC) was Studied in three models of stomach ulcerative lesions induction: Subcutaneous injection of indomethacin, and stress induced by either intraperitoneal injection of reserpine, or immobilization and holding in the cold (4degreesC, 2 hours). Adult Wistar rats (300-400 g) were used for acute (single-dose), repetitive. or subchronic (10 days) administration of WPC prior to treatment with the Ulcerogenic factors. The best protection was achieved in the indomethacin model for repetitive and subchronic experiments, reaching 50.1% and 44%, respectively, inhibition of the ulcerative lesions, which was significant at 1% probability (P < .01). For the immobilization and cold model, maximum inhibition by WPC was 22.1%, and that for the reserpine model was 23.8%. In both models the inhibition was not significant (P > .05) compared with saline (negative control).|
|Editor:||Mary Ann Liebert Inc|
|Citation:||Journal Of Medicinal Food. Mary Ann Liebert Inc, v. 7, n. 3, n. 309, n. 314, 2004.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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