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Type: Artigo de periódico
Title: Monitoring and Detection of Cytomegalovirus in Liver Transplant Recipients
Author: Milan, A
Sampaio, AM
Guardia, AC
Pavan, CR
Andrade, PD
Bonon, SHA
Costa, SCB
Ataide, E
Boin, IFSF
Stucchi, RSB
Abstract: Cytomegalovirus (CMV) is a p-herpesvirus. CMV infections are a common complication contributing to morbidity and mortality after liver transplantation. Among organ transplant recipients, CMV can reactivate from latency during the first 6 months. This prospective study performed from February 2008 to December 2009 examined liver transplant recipients during the first 6 months. Two methods were performed to detect CMV infections: antigenemia (AGM) and nested (PCR). Ninety-four patients, including 72 men (76.6%) and 22 women (23.4%) underwent liver transplantation during this period. We analyzed 575 samples including 465 for AGM and PCR. Forty-three (9.25%) showed positive AGM as detected 2 to 179 days posttransplantation with a mean of 50 days and a median of 35 days, and 93/465 (20%) showed positive PCR at 0 to 186 days posttransplantation with a mean of 31 days and a median of 38 days. Among the 43 antigenemia patients, 38 samples were positive for up to 5 cells 18 of which were PCR-positive. Five samples were positive with more than 5 cells, including 3 that were PCR-positive. Only 4.51% had AGM and were PCR-positive in the same sample. Despite only 9.25% (43/465) showing AGM, the current study suggested the utility of routine monitoring to detect early CMV infection among liver transplantation patients seeking to reduce morbidity and mortality.
Country: EUA
Editor: Elsevier Science Inc
Citation: Transplantation Proceedings. Elsevier Science Inc, v. 43, n. 4, n. 1360, n. 1361, 2011.
Rights: fechado
Identifier DOI: 10.1016/j.transproceed.2011.02.031
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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