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Type: Artigo de periódico
Title: Molecular identification of the HLA-DRB1-DQB1 for diagnosis and follow-up of acute leukemias
Author: Fernandes, TAR
Fukai, R
Souza, CA
Lorand-Metze, I
Magna, LA
Kraemer, MHS
Abstract: We analyzed a group of 45 Brazilian individuals, 30 with acute myeloid leukemia (AML), 15 with acute lymphoid leukemia (ALL) and 100 healthy controls to assess genetic factor risk and HLA association contribution to the disease. Patient rates were compared with age and sex-matched control groups by directly typing the HLA-DRB1/3/4/5 and -DQB1 loci by PCR analysis. We observed significantly increased allelic distribution of HIA-DRB1*07 in AML patients and of HLA-DRB1*03 in ALL patients, which suggests that individuals in both groups are susceptible to the disease. We also found significantly decreased allelic distribution of HIA-DQB1*04 in AML patients and of HLA-DRB1*04 and -DQB1*03 in ALL patients, which suggests protection against the disease. We further found increased HLA-DRB1*07 and -DQB1*02 haplotypes in AML patients, which suggests susceptibility to the disease and decreased HLA-DRB1*04 and -DQB1*03 haplotypes in ALL patients, which also suggests protection against the disease. Future studies with larger and/or multicentric samples will be required for better comprehension of the HLA role in acute leukemia pathogenesis. (C) 2009 Elsevier Inc. All rights reserved.
Subject: Acutes Leukemias
Genetic Association
Country: EUA
Editor: Academic Press Inc Elsevier Science
Citation: Blood Cells Molecules And Diseases. Academic Press Inc Elsevier Science, v. 44, n. 2, n. 69, n. 73, 2010.
Rights: fechado
Identifier DOI: 10.1016/j.bcmd.2009.10.006
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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