Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/57531
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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCXCR7 Is Highly Expressed in Acute Lymphoblastic Leukemia and Potentiates CXCR4 Response to CXCL12pt_BR
dc.contributor.authorMelo, RDCpt_BR
dc.contributor.authorLonghini, ALpt_BR
dc.contributor.authorBigarella, CLpt_BR
dc.contributor.authorBaratti, MOpt_BR
dc.contributor.authorTraina, Fpt_BR
dc.contributor.authorFavaro, Ppt_BR
dc.contributor.authorCampos, PDpt_BR
dc.contributor.authorSaad, STOpt_BR
unicamp.author.emailritacmelo@hotmail.compt_BR
unicamp.authorCarvalho Melo, Rita de Cassia Longhini, Ana Leda Bigarella, Carolina Louzao Baratti, Mariana Ozello Traina, Fabiola Favaro, Patricia Campos, Paula de Melo Olalla Saad, Sara Teresinha Univ Estadual Campinas, Ctr Hematol & Hemoterapia, Sao Paulo, Brazilpt_BR
unicamp.authorFavaro, Patricia Univ Fed Sao Paulo, Dept Ciencias Biol, Sao Paulo, Brazilpt_BR
dc.subject.wosChemokine Receptorpt_BR
dc.subject.wosCell-migrationpt_BR
dc.subject.wosCd34(+) Cellspt_BR
dc.subject.wosHuman Rhabdomyosarcomaspt_BR
dc.subject.wosVascular Endotheliumpt_BR
dc.subject.wosT-lymphocytespt_BR
dc.subject.wosBeta-arrestinpt_BR
dc.subject.wosProteinpt_BR
dc.subject.wosCancerpt_BR
dc.subject.wosSdf-1pt_BR
dc.description.abstractRecently, a novel CXCL12-binding receptor, has been identified. This CXCL12-binding receptor commonly known as CXCR7 (CXC chemokine receptor 7), has lately, based on a novel nomenclature, has received the name ACKR3 (atypical chemokine receptor 3). In this study, we aimed to investigate the expression of CXCR7 in leukemic cells, as well as its participation in CXCL12 response. Interesting, we clearly demonstrated that CXCR7 is highly expressed in acute lymphoid leukemic cells compared with myeloid or normal hematopoietic cells and that CXCR7 contributed to T-acute lymphoid leukemic cell migration induced by CXCL12. Moreover, we showed that the cellular location of CXCR7 varied among T-lymphoid cells and this finding may be related to their migration capacity. Finally, we hypothesized that CXCR7 potentiates CXCR4 response and may contribute to the maintenance of leukemia by initiating cell recruitment to bone marrow niches that were once occupied by normal hematopoietic stem cells.pt
dc.relation.ispartofPlos Onept_BR
dc.relation.ispartofabbreviationPLoS Onept_BR
dc.publisher.citySan Franciscopt_BR
dc.publisher.countryEUApt_BR
dc.publisherPublic Library Sciencept_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculation11324pt_BR
dc.identifier.citationPlos One. Public Library Science, v. 9, n. 1, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber1pt_BR
dc.rightsabertopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.wosidWOS:000330621900012pt_BR
dc.identifier.doi10.1371/journal.pone.0085926pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipINCT-Sanguept_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-07-30T14:03:12Z
dc.date.available2015-11-26T16:43:04Z-
dc.date.accessioned2014-07-30T14:03:12Z
dc.date.accessioned2015-11-26T16:43:04Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:03:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:43:04Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57531
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57531-
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