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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCryptic anhydrobiotic potential in man: Implications in medicinept_BR
dc.contributor.authorPereira, TCpt_BR
dc.contributor.authorLopes-Cendes, Ipt_BR
unicamp.author.emailtcp25@fcm.unicamp.brpt_BR
unicamp.authorPereira, T. C. Lopes-Cendes, I. Univ Estadual Campinas, UNICAMP, Fac Med Sci, Dept Med Genet, BR-13084971 Campinas, SP, Brazilpt_BR
dc.subject.wosDeinococcus-radioduranspt_BR
dc.subject.wosSuspended Animationpt_BR
dc.subject.wosInterferencept_BR
dc.subject.wosRotiferspt_BR
dc.subject.wosRnapt_BR
dc.description.abstractAnhydrobiosis ("life without water") is a state of suspended animation in a dry, ametabolic condition which some species enter before desiccation stress. This state confers resistance to other abiotic stresses such as radiation and heat. Once specimens are rehydrated life resumes. Application of such long-term storage in dry state without loss of viability would bring a considerable advance in organ transplant, maintenance of cell/tissue banks, vaccine storage and transport and many other medical applications. Since anhydrobiosis brings biological advantage to organisms, one would expect it to be positively selected during evolution. Moreover, our still limited understanding of the human genome, together with occasional discoveries of hidden endogenous processes, as well as reports of suspended animation in higher animals leads us to hypothesize the existence of cryptic anhydrobiosis in man. This hypothesis could be tested in laboratory animals and human-derived biological samples using several physical-chemical pre-conditioning/desiccation/rehydration parameters. Finding cryptic anhydrobiosis in human tissues would be a breakthrough in medicine providing means for long-term storage of biological samples in several stressful conditions. (C) 2009 Elsevier Ltd. All rights reserved.pt
dc.relation.ispartofMedical Hypothesespt_BR
dc.relation.ispartofabbreviationMed. Hypothesespt_BR
dc.publisher.cityEdinburghpt_BR
dc.publisher.countryEscóciapt_BR
dc.publisherChurchill Livingstonept_BR
dc.date.issued2009pt_BR
dc.date.monthofcirculationOCTpt_BR
dc.identifier.citationMedical Hypotheses. Churchill Livingstone, v. 73, n. 4, n. 506, n. 507, 2009.pt_BR
dc.language.isoenpt_BR
dc.description.volume73pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage506pt_BR
dc.description.lastpage507pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn0306-9877pt_BR
dc.identifier.wosidWOS:000270374400012pt_BR
dc.identifier.doi10.1016/j.mehy.2009.06.012pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-11-15T21:39:14Z
dc.date.available2015-11-26T16:16:06Z-
dc.date.accessioned2014-11-15T21:39:14Z
dc.date.accessioned2015-11-26T16:16:06Z-
dc.description.provenanceMade available in DSpace on 2014-11-15T21:39:14Z (GMT). No. of bitstreams: 1 WOS000270374400012.pdf: 104786 bytes, checksum: 1ffad95305f19117c4852b907a302b05 (MD5) Previous issue date: 2009en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:16:06Z (GMT). No. of bitstreams: 2 WOS000270374400012.pdf: 104786 bytes, checksum: 1ffad95305f19117c4852b907a302b05 (MD5) WOS000270374400012.pdf.txt: 11304 bytes, checksum: 4dd0234ba6da798250b2712cf426d8a5 (MD5) Previous issue date: 2009en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57432pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/57432
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57432-
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