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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleCorrelations between circulating levels of adipokines and anti-angiogenic factors in women with BMI < 30 and a late-onset preeclampsiapt_BR
dc.contributor.authorEleuterio, NMpt_BR
dc.contributor.authorPalei, ACTpt_BR
dc.contributor.authorMachado, JSRpt_BR
dc.contributor.authorTanus-Santos, JEpt_BR
dc.contributor.authorCavalli, RCpt_BR
dc.contributor.authorSandrim, VCpt_BR
unicamp.author.emailnibiamariana@yahoo.com.brpt_BR
unicamp.authorEleuterio, Nibia Mariana Sandrim, Valeria C. Santa Casa Belo Horizonte, Nucleo Posgrad & Pesquisa, Belo Horizonte, MG, Brazilpt_BR
unicamp.authorPalei, Ana C. T. Univ Estadual Campinas, Fac Med Sci, Dept Pharmacol, Campinas, SP, Brazilpt_BR
unicamp.authorRangel Machado, Jackeline S. Cavalli, Ricardo C. Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Gynecol & Obstet, BR-14049 Ribeirao Preto, SP, Brazilpt_BR
unicamp.authorTanus-Santos, Jose E. Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Pharmacol, BR-14049 Ribeirao Preto, SP, Brazilpt_BR
dc.subjectAdiponectinpt_BR
dc.subjectAngiogenesispt_BR
dc.subjectLeptinpt_BR
dc.subjectPreeclampsiapt_BR
dc.subjectsENGpt_BR
dc.subjectsFLT-1pt_BR
dc.subject.wosAdiponectin Stimulates Angiogenesispt_BR
dc.subject.wosActivated Protein-kinasept_BR
dc.subject.wosSerum Adiponectinpt_BR
dc.subject.wosPlasma Adiponectinpt_BR
dc.subject.wosEndothelial-cellspt_BR
dc.subject.wosSoluble Endoglinpt_BR
dc.subject.wosLeptinpt_BR
dc.subject.wosPregnancypt_BR
dc.subject.wosExpressionpt_BR
dc.subject.wosPlacentapt_BR
dc.description.abstractPreeclampsia (PE) is a pregnancy-specific disease, directly related to high rates of maternal-fetal morbidity and mortality worldwide. Upregulation of anti-angiogenic factors (soluble fms-like tyrosine kinase-1; sFLT-1 and soluble endoglin; sENG) have been suggested to trigger the maternal endothelial dysfunction observed in PE. Studies focusing on the role of adiponectin and leptin, in normal pregnancy as well as in complicated pregnancies, have revelated interesting findings due to the vascular actions of such adipokines. The aims of this study were to compare plasma concentrations of the adiponectin, leptin, sENG and sFLT-1 in preeclamptic (PE, n = 27) and healthy pregnant (HP, n = 36) and to evaluate possible correlations among these adipokines and anti-angiogenic factors. There were significant increases in all biomarkers in PE compared to HP (all p<0.05). In PE group, there were positive strong correlations among adiponectin and leptin with sFLT-1 (r = 0.85 and r = 0.47, respectively) and sEng (r = 0.74 and r = 0.56, respectively). Moreover, we observed significantly correlation among body mass index (BMI) with adiponectin (r = -0.40) and with leptin (r = 0.51) in HP, but not in PE. Moreover, while a negative correlation between sFLT-1 and BMI (r = -0.60) was found in PE, no correlation was observed regarding sEng and BMI. In summary, our findings suggest the existence of a compensatory mechanism that occurs in an attempt to correct this angiogenic imbalance in order to restore the fetal development.pt
dc.relation.ispartofHypertension In Pregnancypt_BR
dc.relation.ispartofabbreviationHypertens. Pregnancypt_BR
dc.publisher.cityLondonpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherInforma Healthcarept_BR
dc.date.issued2014pt_BR
dc.identifier.citationHypertension In Pregnancy. Informa Healthcare, v. 33, n. 1, n. 72, n. 80, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume33pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage72pt_BR
dc.description.lastpage80pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdfpt_BR
dc.sourceWeb of Sciencept_BR
unicamp.cruespUSPpt_BR
dc.identifier.issn1064-1955pt_BR
dc.identifier.eissn1525-6065pt_BR
dc.identifier.wosidWOS:000329131200007pt_BR
dc.identifier.doi10.3109/10641955.2013.837174pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipInstituto de Ensino e Pesquisa da Santa Casa de Belo Horizonte (IEP-SCBH)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2014-07-30T14:02:47Z
dc.date.available2015-11-26T16:42:35Z-
dc.date.accessioned2014-07-30T14:02:47Z
dc.date.accessioned2015-11-26T16:42:35Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T14:02:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:42:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57296
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57296-
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