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Type: Artigo de periódico
Title: Clinical Utility of KAP-1 Expression in Thyroid Lesions
Author: Martins, MB
Marcello, MA
Morari, EC
Cunha, LL
Soares, FA
Vassallo, J
Ward, LS
Abstract: Although there are evidences of the involvement of KAP-1 in other tumors, data on differentiated thyroid carcinomas (DTC) are still lacking. We aimed to evaluate KAP-1 clinical utility in the diagnosis and prognosis of DTC. We used both visual immunohistochemistry and a semiquantitative analysis to evaluate KAP-1 expression in 230 thyroid carcinomas and 131 noncancerous thyroid nodules. There were 43 follicular carcinomas (FC) and 187 papillary thyroid carcinomas (PTC), including 130 classic (CPTC), 4 tall cells (TCPTC), and 53 follicular variants (FVPTC). Patients were followed up for 53.8 +/- 41 months. They were classified as free-of-disease (142 cases) or poor outcome (25 cases-10 deaths), according to their serum Tg levels and image evidences. KAP-1 was identified in 78 % PTC, 75 % TCPTC, 74 % FC, 72 % FVPTC, 55 % FA, 44 % hyperplasia, and 11 % normal thyroid tissues. A ROC analysis identified malignant nodules with 69 % sensitivity and 75 % specificity, using a cutoff of 73.19. In addition to distinguishing benign from malignant thyroid tissues (p < 0.0001), KAP-1 expression differentiated CPTC from nodular hyperplasia (p < 0.0001), CPTC from FA (p = 0.0028), FVPTC from hyperplasia (p = 0.0039), and FC from hyperplasia (p = 0.0025). Furthermore, KAP-1 was more expressed in larger tumors (> 4 cm; p = 0.0038) and in individuals who presented recurrences/metastases (p = 0.0130). We suggest that KAP-1 may help diagnose thyroid nodules, characterize follicular-patterned thyroid lesions, and identify individuals with poor prognosis.
Subject: KAP-1
Thyroid nodule
Follicular thyroid lesions
Country: EUA
Editor: Humana Press Inc
Citation: Endocrine Pathology. Humana Press Inc, v. 24, n. 2, n. 77, n. 82, 2013.
Rights: fechado
Identifier DOI: 10.1007/s12022-013-9245-z
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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