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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleYacon (Smallanthus sonchifolius)-derived fructooligosaccharides improves the immune parameters in the mousept_BR
dc.contributor.authorDelgado, GTCpt_BR
dc.contributor.authorThome, Rpt_BR
dc.contributor.authorGabriel, DLpt_BR
dc.contributor.authorTamashiro, WMSCpt_BR
dc.contributor.authorPastore, GMpt_BR
unicamp.author.emailgrethel@fea.unicamp.brpt_BR
unicamp.authorChoque Delgado, Grethel T. Pastore, Glaucia M. Univ Estadual Campinas, Sch Food Engn, Dept Food Sci, BR-13083862 Sao Paulo, Brazilpt_BR
unicamp.authorThome, Rodolfo Gabriel, Dirce L. Tamashiro, Wirla M. S. C. Univ Estadual Campinas, Inst Biol, Dept Genet Evolut & Bioagents, BR-13083862 Sao Paulo, Brazilpt_BR
dc.subjectYacon rootpt_BR
dc.subjectFructooligosaccharidespt_BR
dc.subjectImmunomodulationpt_BR
dc.subjectPrebioticspt_BR
dc.subjectImmune systempt_BR
dc.subjectMicept_BR
dc.subject.wosSmallanthus-sonchifoliuspt_BR
dc.subject.wosMicept_BR
dc.subject.wosInulinpt_BR
dc.subject.wosRootspt_BR
dc.subject.wosDietpt_BR
dc.subject.wosOligofructosept_BR
dc.subject.wosExtractionpt_BR
dc.subject.wosPrebioticspt_BR
dc.subject.wosInductionpt_BR
dc.subject.wosTolerancept_BR
dc.description.abstractOwing to its high contents of fructooligosaccharides (FOSS), the yacon (Smallanthus sonchifolius) root is used in traditional Andean medicine as a substitute for cane sugar in diabetes and for obesity prevention. This study was designed to test the hypothesis that regular consumption of yacon works to improve the immune system. BALB/c mice were fed with the AIN-93 diet supplemented with 5% commercial FOS or either 3% or 5% yacon FOS for 30 consecutive days. Animals in the control group were fed with nonsupplemented ration. Food intake; weight gain; serum levels of IgA, IgM, and IgG; levels of fecal IgA, production of nitric oxide by peritoneal macrophages, frequencies of T and B lymphocytes in the spleen and peripheral blood, T-cell proliferation, and cytokine production were evaluated in all groups. No significant differences were observed in food intake and weight gain when the experimental and control groups were compared. Also, serum levels of IgA, IgM, and IgG; nitric oxide production in peritoneal macrophages; frequencies of T and B lymphocytes in the spleen and peripheral blood; T-cell proliferation; and production of interleukin (IL)-4, interferon-gamma, IL-10, and tumor necrosis factor a did not differ in the different groups. The intake of FOS, however, led to a significant reduction of the proinflammatory cytokine IL-1 beta in macrophage cultures and elevation of the levels of fecal IgA. Together, these results indicate that the daily consumption of yacon does not exert negative effects on the immune system, helps to preserve an anti-inflammatory state in phagocytic cells, and improves mucosal immunity, possibly preventing the risks associated with autoimmune and metabolic diseases. (c) 2012 Elsevier Inc. All rights reserved.pt
dc.relation.ispartofNutrition Researchpt_BR
dc.relation.ispartofabbreviationNutr. Res.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherPergamon-elsevier Science Ltdpt_BR
dc.date.issued2012pt_BR
dc.date.monthofcirculationNOVpt_BR
dc.identifier.citationNutrition Research. Pergamon-elsevier Science Ltd, v. 32, n. 11, n. 884, n. 892, 2012.pt_BR
dc.language.isoenpt_BR
dc.description.volume32pt_BR
dc.description.issuenumber11pt_BR
dc.description.firstpage884pt_BR
dc.description.lastpage892pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policypt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0271-5317pt_BR
dc.identifier.wosidWOS:000312236600009pt_BR
dc.identifier.doi10.1016/j.nutres.2012.09.012pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2014-07-30T13:52:17Z
dc.date.available2015-11-26T18:05:28Z-
dc.date.accessioned2014-07-30T13:52:17Z
dc.date.accessioned2015-11-26T18:05:28Z-
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dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55673
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55673-
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