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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleBiological Activities of Eco-Friendly Synthesized Hantzsch Adductspt_BR
dc.contributor.authorPacheco, SRpt_BR
dc.contributor.authorBraga, TCpt_BR
dc.contributor.authorda Silva, DLpt_BR
dc.contributor.authorHorta, LPpt_BR
dc.contributor.authorReis, FSpt_BR
dc.contributor.authorRuiz, ALTGpt_BR
dc.contributor.authorde Carvalho, JEpt_BR
dc.contributor.authorModolo, LVpt_BR
dc.contributor.authorde Fatima, Apt_BR
unicamp.author.emaillvmodolo@icb.ufmg.brpt_BR
unicamp.author.emailadefatima@qui.ufmg.brpt_BR
unicamp.authorPacheco, Samira R. Braga, Taniris C. da Silva, Daniel L. Reis, Fabiano S. de Fatima, Angelo Univ Fed Minas Gerais, ICEx, Dept Quim, GEQOB, BR-31270901 Belo Horizonte, MG, Brazilpt_BR
unicamp.authorHorta, Livia P. Reis, Fabiano S. Modolo, Luzia V. Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bot, Grp Estudos Bioquim Plantas GEBioPlan, BR-31270901 Belo Horizonte, MG, Brazilpt_BR
unicamp.authorRuiz, Ana Lucia T. G. de Carvalho, Joao E. Univ Estadual Campinas, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr CP, Campinas, SP, Brazilpt_BR
dc.subject1,4-Dihydropyridinespt_BR
dc.subjectfree radical scavengingpt_BR
dc.subjectantiproliferative activitypt_BR
dc.subjectcancer cellspt_BR
dc.subject.wosOne-pot Synthesispt_BR
dc.subject.wosSolvent-free Conditionspt_BR
dc.subject.wosPolyhydroquinoline Derivativespt_BR
dc.subject.wosAntioxidant Agentspt_BR
dc.subject.wosCitric-acidpt_BR
dc.subject.wosCatalystpt_BR
dc.subject.wosEfficientpt_BR
dc.subject.wosN-aryl-1,4-dihydropyridinespt_BR
dc.subject.wos4-componentpt_BR
dc.subject.wosCancerpt_BR
dc.description.abstractFourteen Hantzsch adducts with different substituents at the C-4 position were synthesized through multicomponent reactions by using citric or lactic acid as catalysts. To the best of our knowledge, this is the first report on the synthesis of such a class of compounds based on multicomponent reactions catalyzed by non-toxic organic acids. The potential to scavenge reactive nitrogen/oxygen species (RNS/ROS) and the ability to inhibit cancer cell growth were then investigated. Among the synthesized compounds, adduct 15 was the most promising free radical scavenger, while adduct 20 was shown to have a wider spectrum of action on the cancer cells studied. These results highlight Hantzsch adducts as lead compounds for obtaining new free radical scavengers and anticancer agents.pt
dc.relation.ispartofMedicinal Chemistrypt_BR
dc.relation.ispartofabbreviationMed. Chem.pt_BR
dc.publisher.citySharjahpt_BR
dc.publisher.countryEmirados Árabes Unidospt_BR
dc.publisherBentham Science Publ Ltdpt_BR
dc.date.issued2013pt_BR
dc.date.monthofcirculationSEPpt_BR
dc.identifier.citationMedicinal Chemistry. Bentham Science Publ Ltd, v. 9, n. 6, n. 889, n. 896, 2013.pt_BR
dc.language.isoenpt_BR
dc.description.volume9pt_BR
dc.description.issuenumber6pt_BR
dc.description.firstpage889pt_BR
dc.description.lastpage896pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1573-4064pt_BR
dc.identifier.eissn1875-6638pt_BR
dc.identifier.wosidWOS:000326088000013pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.date.available2014-07-30T13:52:08Z
dc.date.available2015-11-26T16:41:17Z-
dc.date.accessioned2014-07-30T13:52:08Z
dc.date.accessioned2015-11-26T16:41:17Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T13:52:08Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:41:17Z (GMT). No. of bitstreams: 0 Previous issue date: 2013en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55584
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55584-
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