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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleBeta-Globin Gene Cluster Haplotypes in Afro-Uruguayans from Two Geographical Regions (South and North)pt_BR
dc.contributor.authorDa Luz, Jpt_BR
dc.contributor.authorKimura, EMpt_BR
dc.contributor.authorCosta, FFpt_BR
dc.contributor.authorSonati, MDpt_BR
dc.contributor.authorSans, Mpt_BR
unicamp.author.emailmsans@fhuce.edu.uypt_BR
unicamp.authorSans, Monica Univ Republica, Dept Antropol Biol, Fac Humanidades & Ciencias Educ, Montevideo 11200, Uruguaypt_BR
unicamp.authorDa Luz, Julio Univ Republica, Fac Med, Dept Genet, Montevideo 11200, Uruguaypt_BR
unicamp.authorKimura, Elza Miyuki Sonati, Maria de Fatima Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, Sao Paulo, Brazilpt_BR
unicamp.authorCosta, Fernando Ferreira Univ Estadual Campinas, Fac Ciencias Med, Hemoctr, Sao Paulo, Brazilpt_BR
dc.subject.wosDna Polymorphismspt_BR
dc.subject.wosHuman-populationspt_BR
dc.subject.wosAmazon Regionpt_BR
dc.subject.wosAfricanpt_BR
dc.subject.wosFlowpt_BR
dc.subject.wosDescendantspt_BR
dc.subject.wosThalassemiapt_BR
dc.subject.wosBrazilianspt_BR
dc.subject.wosEvolutionpt_BR
dc.subject.wosAdmixturept_BR
dc.description.abstractThe beta-globin gene cluster haplotypes were identified in 52 and 40 chromosomes from two Afro-Uruguayan populations located in the South and North of the country, respectively. In both regions, the 5'haplotype 2 (+ - - - -), characteristic of non-African populations, was the most frequent, reflecting a strong process of admixture in Afro-Uruguayans (0.355 and 0.262, respectively). The haplotypes 3 (- - - - +) and 4 (- + - - +), characteristics of African sub-Saharan populations, present inverse frequencies in North and South: whereas in the South haplotype 3 is the second most frequent (0.232), and haplotype 4 presents a low frequency (0.019), in the North haplotype 4 is the third most frequent (0.140), and haplotype 3 only reaches an intermediate frequency (0.088). The pairwise F(ST) and the exact test of differentiation show genetic heterogeneity between both regions. Nei's genetic distance show that South and North present affinities with Bantu groups, although the North present the smallest genetic distance with the Mandenka, a Senegalese population. With respect to 3' haplotypes, haplotype I was the most frequent in both populations, followed by haplotype 11, characteristic of sub-Saharan Africans. The high frequencies of haplotype III-Asian could indicate admixture with Native American populations. The differences observed between both Uruguayan regions could be explained by microevolutionary events as genetic drift, founder effects, differential admixture, and/or distinct origin of the African slaves introduced in those regions. Am. J. Hum. Biol. 22:124-128, 2010. (C) 2009 Wiley-Liss, Inc.pt
dc.relation.ispartofAmerican Journal Of Human Biologypt_BR
dc.relation.ispartofabbreviationAm. J. Hum. Biol.pt_BR
dc.publisher.cityHobokenpt_BR
dc.publisher.countryEUApt_BR
dc.publisherWiley-lisspt_BR
dc.date.issued2010pt_BR
dc.date.monthofcirculationJAN-FEBpt_BR
dc.identifier.citationAmerican Journal Of Human Biology. Wiley-liss, v. 22, n. 1, n. 124, n. 128, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume22pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage124pt_BR
dc.description.lastpage128pt_BR
dc.rightsfechadopt_BR
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlpt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn1042-0533pt_BR
dc.identifier.wosidWOS:000272947000015pt_BR
dc.identifier.doi10.1002/ajhb.20961pt_BR
dc.description.sponsorshipPEDECIBA, Uruguaypt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsordocumentnumberFAPESP [02/13801-7]pt
dc.date.available2014-11-19T23:26:42Z
dc.date.available2015-11-26T18:07:13Z-
dc.date.accessioned2014-11-19T23:26:42Z
dc.date.accessioned2015-11-26T18:07:13Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T18:07:13Z (GMT). No. of bitstreams: 2 WOS000272947000015.pdf: 86643 bytes, checksum: 5dd3921dedff983051ed86bf711668e9 (MD5) WOS000272947000015.pdf.txt: 29838 bytes, checksum: 9e6a38078b5e3fcaed4ff9c732ea183e (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55432pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/55432
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55432-
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