Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/55175
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampDe Nucci, Gilbertopt_BR
dc.contributor.authorunicampBaracat, Juliana Signoript_BR
dc.contributor.authorunicampAntunes, Edsonpt_BR
dc.typeArtigopt_BR
dc.titleAtypical beta-adrenoceptor subtypes mediate relaxations of rabbit corpus cavernosumpt_BR
dc.title.alternativeen
dc.contributor.authorTeixeira, C.E.pt_BR
dc.contributor.authorDe Nucci, G.pt_BR
dc.contributor.authorBaracat, J.S.pt_BR
dc.contributor.authorAntunes, E.pt_BR
dc.contributor.authorZanesco, A.pt_BR
dc.subjectAntagonistas adrenérgicos betapt_BR
dc.subjectÓxido nítricopt_BR
dc.subject.otherlanguageAdrenergic beta-antagonistspt_BR
dc.subject.otherlanguageNitric oxidept_BR
dc.description.abstractThis study was performed to characterize the beta-adrenoceptor population in rabbit isolated corpus cavernosum (RbCC) by using nonselective and selective beta-adrenoceptor agonists and antagonists in functional assays. Metaproterenol, ritodrine, fenoterol, and 8-hydroxy-5-[(1R)-1-hydroxy-2-[N-[(1R)-2-(rho-methoxy-phenyl)1-methylethyl] amino] ethyl] carbostyril (TA 2005) (3-100 nmol each) dose dependently relaxed the RbCC preparations. These relaxations were markedly reduced by N-omega-nitro-L-arginine methyl ester (L-NAME; 10 muM) and 1H-[1,2,4]-oxadiazolo-[4,3,-a]quinoxalin-1-one (ODQ) (10 muM), whereas the adenylyl cyclase inhibitor SQ 22,536 [9-(2-tetrahydrofuryl)adenine] (10 muM) had no effect. In contrast, neither L-NAME nor ODQ affected the isoproterenol-induced RbCC relaxations, but SQ 22,536 abolished this response. Sildenafil (1 muM) significantly potentiated the relaxations induced by beta(2)-agonists without affecting the isoproterenol-evoked relaxations. Rolipram (10 muM) enhanced the relaxations elicited by isoproterenol but had no effect on those induced by the selective beta(2) agonists. Propranolol and (+/-)-1-[2,3-(dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride (ICI 118,551) determined a rightward shift in the concentration-response curves to isoproterenol in a noncompetitive manner with a reduction of maximum response at the highest antagonist concentration, with the slope values significantly different from unity. Propranolol and ICI 118,551 had no effect on the relaxations elicited by fenoterol, TA 2005, metaproterenol, and ritodrine. Atenolol and 1-[2-((3-carbamoyl-4-hydroxy)phenoxy) ethylamino]-3-[4-(1-methyl-4-trifluoromethyl-2-imidazolyl)-phenoxy]2-propanol methanesulfonate (CGP 20712A) (0.1-10 muM) failed to affect the relaxations induced by all tested beta-adrenoceptor agonists. Our study revealed the existence of two atypical beta-adrenoceptors in the rabbit erectile tissue. Isoproterenol relaxes the rabbit cavernosal tissue by activating atypical beta-adrenoceptors coupled to adenylyl cyclase pathway, whereas the selective beta2-adrenoceptor agonists relax the RbCC tissue through another atypical beta-adrenoceptor subtype coupled to nitric oxide release from the sinusoidal endotheliumpt
dc.description.eventAmerican Society for Pharmacology and Experimental Therapeuticspt_BR
dc.relation.ispartofJournal of pharmacology and experimental therapeuticspt_BR
dc.relation.ispartofabbreviationJ pharmacol exp therpt_BR
dc.publisher.cityRockville, MDpt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherAmerican Society for Pharmacology and Experimental Therapeuticspt_BR
dc.date.issued2004pt_BR
dc.date.monthofcirculationMaypt_BR
dc.identifier.citationJournal Of Pharmacology And Experimental Therapeutics. Amer Soc Pharmacology Experimental Therapeutics, v. 309, n. 2, n. 587, n. 593, 2004.pt_BR
dc.language.isoengpt_BR
dc.description.volume309pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage587pt_BR
dc.description.lastpage593pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0022-3565pt_BR
dc.identifier.eissn1521-0103pt_BR
dc.identifier.doi10.1124/jpet.103.062026pt_BR
dc.identifier.urlhttp://jpet.aspetjournals.org/content/early/2004/01/29/jpet.103.062026pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumbersem informaçãopt_BR
dc.date.available2014-11-17T04:52:18Z
dc.date.available2015-11-26T16:45:02Z-
dc.date.accessioned2014-11-17T04:52:18Z
dc.date.accessioned2015-11-26T16:45:02Z-
dc.description.provenanceMade available in DSpace on 2014-11-17T04:52:18Z (GMT). No. of bitstreams: 1 WOS000220972900020.pdf: 171002 bytes, checksum: ae427e43dea692bfefbfa08ac16c5e0d (MD5) Previous issue date: 2004 Bitstreams deleted on 2020-05-18T20:41:00Z: WOS000220972900020.pdf,. Added 1 bitstream(s) on 2020-05-19T14:30:47Z : No. of bitstreams: 2 000220972900020.pdf: 250105 bytes, checksum: ff79c807d5119516416b55c2e5add3f9 (MD5) WOS000220972900020.pdf.txt: 40889 bytes, checksum: 89864164466550dfccb8c6e78852ad66 (MD5)en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:45:02Z (GMT). No. of bitstreams: 2 WOS000220972900020.pdf: 171002 bytes, checksum: ae427e43dea692bfefbfa08ac16c5e0d (MD5) WOS000220972900020.pdf.txt: 40889 bytes, checksum: 89864164466550dfccb8c6e78852ad66 (MD5) Previous issue date: 2004en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55175pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/55175
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55175-
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Farmacologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.description.abstractalternative-
dc.identifier.source000220972900020-
dc.creator.orcid0000-0002-4346-7941pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-2201-8247pt_BR
dc.type.formArtigo originalpt_BR
dc.description.eventsponsorBethesda, MDpt_BR
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