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Type: Artigo de periódico
Title: Association of HLA-A, -B, -C genes and TNF microsatellite polymorphism with psoriasis vulgaris: a study of genetic risk in Brazilian patients
Author: Biral, AC
Magalhaes, RF
Wastowski, IJ
Simoes, R
Donadi, EA
Simoes, AL
Mendes, CT
Tanaka, AM
Kraemer, MHS
Abstract: This study investigated the genetic association of HLA class I genes and TNF-alpha microsatellites. HLA-A, -B, -C typing was carried out in 92 psoriasis vulgaris patients and 160 healthy individuals using a PCR-SSP method. 70 patients and 71 controls were typed for five microsatellite polymorphisms, TNFa-e. HLA-B*13 Cw*06, HLA-B*57 Cw*06 and HLA-B*39 Cw*12 haplotypes were found to be increased in patients with psoriasis type I when compared to controls, which could determine the susceptibility to development of psoriasis. TNFa4, TNFb1, TNFe1 and TNFa2 b1 c2 d4 el haplotypes showed a decreased frequency (p < 0.05) in psoriasis patients when compared to controls. HLA-B*13 allele and HLA-B * 13 Cw*06, TNFa11 b4 c1 d3 e3 haplotypes showed increased frequencies (p < 0.05) in patients with type II psoriasis, which suggests susceptibility to the onset of psoriasis. Our results detected polymorphisms of the HLA class I and microsatellite TNF locus which could be markers of genetic predisposition to the disease.
Subject: brazilian patients
genetic predisposition
HLA-A, -B, -C genes
microsatellites TNF
psoriasis vulgaris
risk haplotypes
Country: França
Editor: John Libbey Eurotext Ltd
Citation: European Journal Of Dermatology. John Libbey Eurotext Ltd, v. 16, n. 5, n. 523, n. 529, 2006.
Rights: fechado
Identifier DOI: 10.1684/ejd.2006.0025
Date Issue: 2006
Appears in Collections:Unicamp - Artigos e Outros Documentos

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