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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleAntiulcerogenic activity of crude ethanol extract and some fractions obtained from aerial parts of Artemisia annua L.pt_BR
dc.contributor.authorDias, PCpt_BR
dc.contributor.authorFoglio, MApt_BR
dc.contributor.authorPossenti, Apt_BR
dc.contributor.authorNogueira, DCFpt_BR
dc.contributor.authorde Carvalho, JEpt_BR
unicamp.authorUNICAMP, CPQBA, BR-13083970 Campinas, SP, Brazil Univ Estadual Campinas, Dept Farmacol, BR-13083970 Campinas, SP, Brazilpt_BR
dc.subjectArtemisia annuapt_BR
dc.subjectantiulcer activitypt_BR
dc.subjectmedicinal plantpt_BR
dc.description.abstractThe resulting enriched sesquiterpene lactone fraction and the crude ethanol extract of Artemisia annua L. aerial parts, showed antiulcerogenic activity when administered orally, on the indomethacin induced ulcer in rats. The sesquiterpene lactone fraction yielded three different polarity fractions on column chromatography as follows: non-polar, medium polarity and polar fraction, When submitted to the same indomethacin-induced ulcer in rats they resulted in different levels of inhibition of the ulcerative lesion index. The participation of nitric oxide was evaluated on an ethanol-induced ulcer model which had a previous administration of L-NAME, a NO-synthase inhibitor. Under these conditions, the medium polarity fraction maintained the antiulcerogenic activity, suggesting that nitric oxide could not be involved in the antiulcerogenic activity. When the animal groups were treated with N-ethylmaleimide, an alkylator of sulphhydryl groups, using the same experimental model, the medium polarity fraction maintained its antiulcerogenic activity, suggesting that the pharmacological mechanism is not related to non-protein sulphydryl compounds. On the ethanol-induced ulcer with previous indomethacin treatment, the medium polarity fraction lost its antiulcerogenic activity indicating that the active compounds of Artemisia annua L. increase the prostaglandin levels in the gastric mucosa. This hypothesis was reinforced by an increase of adherent mucus production by the gastric mucosa, produced by the medium polarity fraction on the hypothermic restraint stress induced ulcer model. Copyright (C) 2001 John Wiley & Sons,
dc.relation.ispartofPhytotherapy Researchpt_BR
dc.relation.ispartofabbreviationPhytother. Res.pt_BR
dc.publisher.cityW Sussexpt_BR
dc.publisherJohn Wiley & Sons Ltdpt_BR
dc.identifier.citationPhytotherapy Research. John Wiley & Sons Ltd, v. 15, n. 8, n. 670, n. 675, 2001.pt_BR
dc.sourceWeb of Sciencept_BR
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