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Type: Artigo de periódico
Title: Antiproliferative properties of polyketides isolated from Virola sebifera leaves
Author: Denny, C
Zacharias, ME
Ruiz, ALTG
do Amaral, MDE
Bittrich, V
Kohn, LK
Sousa, IMD
Rodrigues, RAF
de Carvalho, JE
Foglio, MA
Abstract: An activity-guided fractionation of Virola sebifera Aubl. methylene chloride-soluble fraction provided novel 3,5-dihydro-2-(1'-oxo-3'-hexadecenyl)-2-cyclohexen-1-one (3), two known lignans (1, 2) and dehydro hexadecanoyl resorcinol (4). Isolation and purification were conducted with the application of column chromatography and structures were assigned by spetral analysis (1D and 2D NMR, HREIMS). Compounds 1-4 were evaluated for cytotoxic activities against human tumour cell lines UACC62 (melanoma), MCF-7 (breast), NCI 460 (lung, non-small cells), OVCAR03 (ovarian), PC-03 (prostate), HT-29 (colon), 786-0 (renal) and NCI-ADR (breast expressing phenotype multiple drugs resistance) in vitro. The new polyketide (3) showed selectivity against human OVCAR03 and NCI-ADR cell lines, ranging from 2 to 4 mu g/mL. Copyright (c) 2007 John Wiley & Sons, Ltd.
Subject: myristicaceae
virola sebifera
3,5-dihydro-2-(1 '-oxo-3 '-hexadecenyl)-2-cyclohexen-1-one
antiproliferative activity
Country: Inglaterra
Editor: John Wiley & Sons Ltd
Citation: Phytotherapy Research. John Wiley & Sons Ltd, v. 22, n. 1, n. 127, n. 130, 2008.
Rights: fechado
Identifier DOI: 10.1002/ptr.2251
Date Issue: 2008
Appears in Collections:Unicamp - Artigos e Outros Documentos

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