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Type: Artigo de periódico
Title: Analysis of familial incidence of non-syndromic cleft lip and palate in a Brazilian population
Author: Martelli, DR
Bonan, PRF
Soares, MC
Paranaiba, LR
Martelli, H
Abstract: Background: The purpose of this study is to follow the familial incidence of non-syndromic or isolated cleft lip, with or without cleft palate (NSCL/P), and to analyze the relationships between the type of NSCL/P in the affected individual and his/her parent, looking at children in the first grade. Material and Methods: To investigate the familial incidence of NSCL/P we analyzed the records of 185 patients from 2004-2008, retrospectively. Detailed histories were collected regarding the familial incidence of NSCL/P. For the 185 individuals, the relationship between the type of NSCL/P and the sociodemographic and personal characteristics of the affected person and her/his cleft relatives was obtained. Results: The individuals were 42 carriers of CL, 109 with CLP (joined in one group) and 34 with CP (p<0.001). Of the total of participants, 65 (35.13%) presented a positive history of cleft in their families and 120 (64.86%) presented a negative history (p<0.001). There were differences between the cleft groups according to types of cleft and positive familial history (p<0.001). In both groups, the relatives with higher incidence of NSCL/P were cousins, with the same pattern of distribution between the two groups (p=0.175). Conclusions: Most frequently, fissures result from CL/CLP with no familial history. However, CL/CLP was found in familial cases and cousins were the relative type more likely to be affected.
Subject: Cleft palate
cleft lip
Country: Espanha
Editor: Medicina Oral S L
Citation: Medicina Oral Patologia Oral Y Cirugia Bucal. Medicina Oral S L, v. 15, n. 6, n. E898, n. E901, 2010.
Rights: aberto
Identifier DOI: 10.4317/medoral.15.e898
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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