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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA prospective study on the prevalence and risk factors for neonatal thrombocytopenia and platelet alloimmunization among 9332 unselected Brazilian newbornspt_BR
dc.contributor.authorCastro, Vpt_BR
dc.contributor.authorKroll, Hpt_BR
dc.contributor.authorOriga, AFpt_BR
dc.contributor.authorFalconi, MApt_BR
dc.contributor.authorMarques, SBDpt_BR
dc.contributor.authorMarba, STpt_BR
dc.contributor.authorPassini, Rpt_BR
dc.contributor.authorAnnichino-Bizzacchi, JMpt_BR
dc.contributor.authorCosta, FFpt_BR
dc.contributor.authorSantoso, Spt_BR
dc.contributor.authorArruda, VRpt_BR
unicamp.author.emailvagner@unicamp.brpt_BR
unicamp.authorUniv Estadual Campinas, Hematol & Transfus Ctr, UNICAMP, Dept Neonatol, Campinas, SP, Brazil Univ Estadual Campinas, Dept Obstet & Gynecol, UNICAMP, Campinas, SP, Brazil NSTOB Inst, German Red Cross Blood Transfus Serv, Dessau, Germany Univ Giessen, Inst Clin Immunol & Transfus Med, D-6300 Giessen, Germany Univ Penn, Sch Med, Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USApt_BR
dc.subject.wosFetal Thrombocytopeniapt_BR
dc.subject.wosGene-frequenciespt_BR
dc.subject.wosMaipa Assaypt_BR
dc.subject.wosAntigenspt_BR
dc.subject.wosAntibodiespt_BR
dc.subject.wosInfantspt_BR
dc.subject.wosSystemspt_BR
dc.subject.wosDnapt_BR
dc.description.abstractBACKGROUND: Neonatal thrombocytopenia (NT) occurs in 0.5 to 0.9% of unselected Caucasian newborns. However, the prevalence of this complication in other populations is unknown. In this study the prevalence/causes of NT was determined in Brazilian newborns, a population characterized by admixture among Indigenous, Africans, and Caucasians. STUDY DESIGN: A prospective study was carried out in a 3-year period, to determine the prevalence and causes of thrombocytopenia in cord blood samples. Genotyping for HPA 1-5 systems was performed in pairs of mother/neonates with and without thrombocytopenia. All mothers with genotypic mismatches from each group were tested for HPA-specific antibody using the MAIPA technique to identify alloimmunization. RESULTS: Platelet counts < 100 x 10(9)/L were detected in 1.5% of 9,332 unselected newborns. In 0.15%, platelet count was < 50 x 10(9)/L. Clinically significant bleeding was rare. Underlying diseases were present in 48% of the thrombocytopenic cases. HPA 1-5 system genotype mismatches occurred in 50% of gestations, but did not predict the risk for thrombocytopenia. Notably, mismatched genotypes for HPA-5 were slightly increased in the thrombocytopenic group. The presence of anti-HPA-5b antibodies was observed in 0.05% of unselected pregnancies, but increased to 12% among mothers of neonates with thrombocytopenia and mismatched genotype (N = 51). CONCLUSIONS: Neonatal thrombocytopenia is common among Brazilian newborns at rates comparable with those described among Caucasians. These data suggest that screening for genotypic HPA mismatch, followed by an HPA-specific immunoassay system, particularly for the HPA-5 system, among mothers of newborns with thrombocytopenia in our population would allow the identification of pregnancies at risk of alloimmune thrombocytopenia.pt
dc.relation.ispartofTransfusionpt_BR
dc.relation.ispartofabbreviationTransfusionpt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryInglaterrapt_BR
dc.publisherBlackwell Publishingpt_BR
dc.date.issued2007pt_BR
dc.date.monthofcirculationJANpt_BR
dc.identifier.citationTransfusion. Blackwell Publishing, v. 47, n. 1, n. 59, n. 66, 2007.pt_BR
dc.language.isoenpt_BR
dc.description.volume47pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage59pt_BR
dc.description.lastpage66pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0041-1132pt_BR
dc.identifier.wosidWOS:000242963100012pt_BR
dc.identifier.doi10.1111/j.1537-2995.2007.01064.xpt_BR
dc.date.available2014-11-17T01:39:51Z
dc.date.available2015-11-26T16:34:55Z-
dc.date.accessioned2014-11-17T01:39:51Z
dc.date.accessioned2015-11-26T16:34:55Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T16:34:55Z (GMT). No. of bitstreams: 2 WOS000242963100012.pdf: 156213 bytes, checksum: 8317b0f7c324476881beab09c84e67cb (MD5) WOS000242963100012.pdf.txt: 34012 bytes, checksum: 2e41a75ce62529c64e5a9c273fcb4f35 (MD5) Previous issue date: 2007en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53637pt_BR
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/53637
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53637-
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