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Type: Artigo de periódico
Title: Mauritic acid: a new dammarane triterpene from the roots of Mauritia flexuosa L.f. (Arecaceae)
Author: Koolen, HHF
Soares, ER
da Silva, FMA
de Oliveira, AA
de Souza, AQL
de Medeiros, LS
Rodrigues, E
Cavalcanti, BC
Pessoa, CO
Moraes, MO
Salvador, MJ
de Souza, ADL
Abstract: A new dammarane triterpene named mauritic acid (1) was isolated from the roots of Mauritia flexuosa L.f. The complete structural assignment of this new compound was elucidated from spectroscopic methods. Moreover, this compound was evaluated for its cytotoxicity against human cancer cell lines (OVCAR-8, PCM3, NCIH358M and different leukaemia cell strains). The mauritic acid presented significant cytotoxicity against OVCAR-8, PCM3 and NCIH358M cell lines with IC50 3.02, 2.39 and 6.19M, respectively. The triterpenes 1 and 2 were also tested for their antimicrobial activity against 15 strains of microorganisms, including fungi and bacteria, with the best minimal inhibitory concentration values ranging from 50.8 to 203.5M.
Subject: antimicrobial activity
cytotoxic activity
Mauritia flexuosa
Country: Inglaterra
Editor: Taylor & Francis Ltd
Citation: Natural Product Research. Taylor & Francis Ltd, v. 27, n. 22, n. 2118, n. 2125, 2013.
Rights: fechado
Identifier DOI: 10.1080/14786419.2013.793685
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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