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Type: Artigo de periódico
Title: Maternal Polymorphisms in Folic Acid Metabolic Genes Are Associated with Nonsyndromic Cleft Lip and/or Palate in the Brazilian Population
Author: Bufalino, A
Paranaiba, LMR
de Aquino, SN
Martelli, H
Swerts, MSO
Coletta, RD
Abstract: BACKGROUND: Polymorphisms in genes that are involved in folic acid metabolism may be important maternal risk factors for the birth of a child with nonsyndromic cleft lip and/or palate (NSCL/P). The aim of this study was to determine the involvement of polymorphic variants in four genes (MTHFR, MTHFD1, MTR, and SLC19A1) that encode proteins related to folic acid metabolism in the women with susceptibility for having a child with NSCL/P. METHODS: DNA samples from 106 mothers of children with NSCL/P (case group) and from 184 mothers of healthy children (control group) were genotyped by polymerase chain reaction associated with restriction fragment length polymorphism (PCR-RFLP). RESULTS: One of 29 polymorphisms was associated with significantly increased maternal risk for NSCL/P. Mothers exhibiting the A variant allele (GA genotype) of the MTHFR rs2274976 polymorphism demonstrated a similar to 6 times increased risk for having a child with NSCL/P compared to G allele carriers (OR, 5.76; 95% CI, 3.32-9.99, p = 0.000001). Among mothers who did not use vitamins, the OR of NSCL/P was increased to 8.34 (95% CI, 3.75-18.55, p = 0.000001) in the presence of the GA genotype of the MTHFR rs2274976 polymorphism compared to those with the GG genotype. Gene-gene interaction analysis showed that the combination of MTHFR rs2274976, MTHFD1 rs2236225, and SLC19A1 rs1051266 was the best model for prediction of maternal risk for NSCL/P. CONCLUSION: The findings of the present study suggested that genetic variants of folic acid metabolic genes may modulate maternal susceptibility for having an offspring with NSCL/P. Birth Defects Research (Part A) 88: 980-986, 2010. (C) 2010 Wiley-Liss, Inc.
Subject: nonsyndromic cleft lip and/or palate
folic acid
maternal marker
Country: EUA
Editor: Wiley-blackwell
Citation: Birth Defects Research Part A-clinical And Molecular Teratology. Wiley-blackwell, v. 88, n. 11, n. 980, n. 986, 2010.
Rights: fechado
Identifier DOI: 10.1002/bdra.20732
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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