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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.title3T MRI Quantification of Hippocampal Volume and Signal in Mesial Temporal Lobe Epilepsy Improves Detection of Hippocampal Sclerosispt_BR
dc.contributor.authorCoan, ACpt_BR
dc.contributor.authorKubota, Bpt_BR
dc.contributor.authorBergo, FPGpt_BR
dc.contributor.authorCampos, BMpt_BR
dc.contributor.authorCendes, Fpt_BR
unicamp.author.emailfcendes@unicamp.brpt_BR
unicamp.authorCoan, A. C. Kubota, B. Bergo, F. P. G. Campos, B. M. Cendes, F. Univ Estadual Campinas, Dept Neurol, Neuroimaging Lab, Sao Paulo, Brazilpt_BR
dc.subject.wosAmygdalapt_BR
dc.subject.wosAtrophypt_BR
dc.subject.wosRelaxometrypt_BR
dc.subject.wosLobectomypt_BR
dc.subject.wosSurgerypt_BR
dc.description.abstractBACKGROUND AND PURPOSE: In mesial temporal lobe epilepsy, MR imaging quantification of hippocampal volume and T2 signal can improve the sensitivity for detecting hippocampal sclerosis. However, the current contributions of these analyses for the diagnosis of hippocampal sclerosis in 3T MRI are not clear. Our aim was to compare visual analysis, volumetry, and signal quantification of the hippocampus for detecting hippocampal sclerosis in 3T MRI. MATERIALS AND METHODS: Two hundred three patients with mesial temporal lobe epilepsy defined by clinical and electroencephalogram criteria had 3T MRI visually analyzed by imaging epilepsy experts. As a second step, we performed automatic quantification of hippocampal volumes with FreeSurfer and T2 relaxometry with an in-house software. MRI of 79 healthy controls was used for comparison. RESULTS: Visual analysis classified 125 patients (62%) as having signs of hippocampal sclerosis and 78 (38%) as having normal MRI findings. Automatic volumetry detected atrophy in 119 (95%) patients with visually detected hippocampal sclerosis and in 10 (13%) with visually normal MR imaging findings. Relaxometry analysis detected hyperintense T2 signal in 103 (82%) patients with visually detected hippocampal sclerosis and in 15 (19%) with visually normal MR imaging findings. Considered together, volumetry plus relaxometry detected signs of hippocampal sclerosis in all except 1 (99%) patient with visually detected hippocampal sclerosis and in 22 (28%) with visually normal MR imaging findings. CONCLUSIONS: In 3T MRI visually inspected by experts, quantification of hippocampal volume and signal can increase the detection of hippocampal sclerosis in 28% of patients with mesial temporal lobe epilepsy.pt
dc.relation.ispartofAmerican Journal Of Neuroradiologypt_BR
dc.relation.ispartofabbreviationAm. J. Neuroradiol.pt_BR
dc.publisher.cityDenvillept_BR
dc.publisher.countryEUApt_BR
dc.publisherAmer Soc Neuroradiologypt_BR
dc.date.issued2014pt_BR
dc.date.monthofcirculationJANpt_BR
dc.identifier.citationAmerican Journal Of Neuroradiology. Amer Soc Neuroradiology, v. 35, n. 1, n. 77, n. 83, 2014.pt_BR
dc.language.isoenpt_BR
dc.description.volume35pt_BR
dc.description.issuenumber1pt_BR
dc.description.firstpage77pt_BR
dc.description.lastpage83pt_BR
dc.rightsfechadopt_BR
dc.sourceWeb of Sciencept_BR
dc.identifier.issn0195-6108pt_BR
dc.identifier.eissn1936-959Xpt_BR
dc.identifier.wosidWOS:000333568100016pt_BR
dc.identifier.doi10.3174/ajnr.A3640pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsordocumentnumberFAPESP [2005/56578-4, 2009/54552-9]pt
dc.date.available2014-07-30T13:38:57Z
dc.date.available2015-11-26T16:34:15Z-
dc.date.accessioned2014-07-30T13:38:57Z
dc.date.accessioned2015-11-26T16:34:15Z-
dc.description.provenanceMade available in DSpace on 2014-07-30T13:38:57Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.description.provenanceMade available in DSpace on 2015-11-26T16:34:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2014en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/52670
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/52670-
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