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Type: Artigo de periódico
Title: Long-Term Resistance Training Is Associated with Reduced Circulating Levels of IL-6, IFN-Gamma and TNF-Alpha in Elderly Women
Author: Cordova, C
Lopes-e-Silva, F
Pires, AS
Souza, VC
Brito, CJ
Moraes, CF
Sposito, AC
Nobrega, OT
Abstract: Objective: The increase in inflammatory activity associated with aging is a characteristic of chronic disease processes that accounts for most of the mortality in the elderly. Resistance training (RT) has been shown to promote metabolic and functional benefits in this population. The objective of this study was to investigate the association between long-term RT and circulating levels of the proinflammatory mediators IL-6, TNF-alpha. and IFN-gamma in elderly women. Methods: This cross-sectional study included 54 older outpatients divided into a group that underwent RT (n = 28) for an average of 8.6 +/- 0.3 months and a sedentary group (n = 26). Measurements were taken only at the end of the intervention, and cytokine values were log-transformed. Dietary intake was controlled as a confounding factor. Results: The RT group presented reduced levels of log(10)IFN-gamma (approx. 45%; p = 0.003), log(10)IL-6 (approx. 30%; p = 0.002) and log(10)TNF-alpha (approx. 22%; p = 0.036). Total caloric intake and systolic arterial blood pressure were significantly lower in the RT group (p = 0.001 and p = 0.022, respectively). Pearson's product moment correlation test revealed a negative association between the fat-free mass (FFM) index and log-transformed IL-6 levels (p = 0.03; n = 54) and a trend towards significance for the correlation between the FFM index and log(10)IFN-gamma (p = 0.05; n = 54). Conclusion: Long-term, moderate-intensity RT in elderly women is associated with lower circulating levels of cytokines that are potentially implicated in disorders associated with physical inactivity and aging. Copyright (C) 2011 S. Karger AG, Basel
Subject: Resistance training
Chronic disease
Older women
Country: Suíça
Editor: Karger
Citation: Neuroimmunomodulation. Karger, v. 18, n. 3, n. 165, n. 170, 2011.
Rights: fechado
Identifier DOI: 10.1159/000323396
Date Issue: 2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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