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Type: Artigo de periódico
Title: Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection
Author: Guardia, Ana Carolina
Stucchi, Raquel Silveira Bello
Milan, Arlete
Costa, Sandra Cecília Botelho
Boin, Ilka de Fátima Santana Ferreira
Abstract: Herpesvirus reactivation is common after liver transplantation.OBJECTIVE: Analyze the presence of cytomegalovirus (HCMV) and human herpesvirus-6 (HHV-6) DNA in liver donor biopsies, seeking to better understand issues involving human donor leukocyte antigens (HLA)-A, B and DR, as well as correlations with acute cellular rejection. METHODS: Fifty-nine liver transplantation patients were investigated for the presence of HCMV and HHV-6 DNA in liver donor biopsies, using the Nested-PCR technique. The clinical donor information and HLA matches were obtained from the São Paulo State Transplant System. The recipients' records regarding acute cellular rejection were studied. RESULTS: Seven (11.8%) biopsies were positive for HCMV DNA and 29 (49%) were positive for HHV-6 DNA. In 14 donors with HLA-DR 15 nine had HHV-6 DNA positive liver biopsy with a tendency for significant association (p=0.09), 22 recipients developed acute cellular rejection and 9/22 were positive for HLA-DR 15 (p=0.03; χ 2=4.51), which was statistically significant in univariate analysis and showed a tendency after multivariate analysis (p=0.08). CONCLUSION: HHV-6 DNA was prevalent in liver donors studied as well as HLA-DR 15. These findings suggest that patients with HLA-DR 15 in liver donor biopsies develop more rejection after liver transplantation.
Subject: Liver transplantation
Human herpesvirus 6
Liver donor biopsies
Editor: Brazilian Society of Infectious Diseases
Citation: Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 18, n. 2, p. 220-224, 2014.
Rights: aberto
Identifier DOI: 10.1016/j.bjid.2013.07.007
Date Issue: 1-Apr-2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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