Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/351938
Type: Outro documento
Title: Novel R-(+)-limonene-based thiosemicarbazones and their antitumor activity against human tumor cell lines
Author: Vandresen, F.
Ruiz, A. L. T. G.
Falzirolli, H.
da Silva-Giardini, A. P. B.
Catharino, R. R.
Batista, S. A. A.
de Oliveira, D. N.
de Carvalho, J. E.
Foglio, M. A.
da Silva, C. C.
Abstract: In an attempt to develop potent and selective antitumor agents, a series of novel thiosemicarbazones derived from a natural monoterpene R-(+)-limonene was synthesized and their antitumor activity was evaluated. Overall, the majority of tested compounds exhibited considerable inhibitory effects on the growth of a wide range of cancer cell lines. Almost all of tested thiosemicarbazones were especially sensitive to prostate cells (PC-3). Derivatives 5, 6, 8, 9, 10, 11 and 13 presented the most potent antitumor activity against PC-3 cells. These compounds showed lower value of GI(50) (0.04-0.05 mu M) than the reference drug paclitaxel, besides a high selectivity for the same cell line. The 4-fluorobenzaldehyde derivative 10 was the most selective compound for prostate cells, while 2-hydroxybenzaldehyde derivative 8 was the most active compound, with potent antitumor activity against all tested cell lines
Subject: Atividade antitumoral
Células cancerosas
Próstata
Country: França
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.ejmech.2014.03.086
Address: https://www.sciencedirect.com/science/article/pii/S0223523414003080
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos
CPQBA - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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