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Type: Artigo
Title: Human herpesvirus-6 and cytomegalovirus DNA in liver donor biopsies and their correlation with HLA matches and acute cellular rejection
Author: Guardia, Ana Carolina
Stucchi, Raquel Silveira Bello
Milana, Arlete
Costa, Sandra Cecília Botelho
Boin, Ilka de Fátima Santana Ferreira
Abstract: Herpesvirus reactivation is common after liver transplantation. Objective: Analyze the presence of cytomegalovirus (HCMV) and human herpesvirus-6 (HHV6) DNA in liver donor biopsies, seeking to better understand issues involving human donor leukocyte antigens (HLA)-A, B and DR, as well as correlations with acute cellular rejection. Methods: Fifty-nine liver transplantation patients were investigated for the presence of HCMV and HHV-6 DNA in liver donor biopsies, using the Nested-PCR technique. The clinical donor information and HLA matches were obtained from the São Paulo State Transplant System. The recipients’ records regarding acute cellular rejection were studied. Results: Seven (11.8%) biopsies were positive for HCMV DNA and 29 (49%) were positive for HHV-6 DNA. In 14 donors with HLA-DR 15 nine had HHV-6 DNA positive liver biopsy with a tendency for significant association (p = 0.09), 22 recipients developed acute cellular rejection and 9/22 were positive for HLA-DR 15 (p = 0.03; 2 = 4.51), which was statistically significant in univariate analysis and showed a tendency after multivariate analysis (p = 0.08). Conclusion: HHV-6 DNA was prevalent in liver donors studied as well as HLA-DR 15. These findings suggest that patients with HLA-DR 15 in liver donor biopsies develop more rejection after liver transplantation
Subject: Citomegalovírus
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.bjid.2013.07.007
Date Issue: 2014
Appears in Collections:FCM - Artigos e Outros Documentos

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