Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/350559
Type: Artigo
Title: Enzymatic synthesis of poly(glycerol sebacate): kinetics, chain growth, and branching behavior
Author: Perin, Giovanni B.
Felisberti, Maria I.
Abstract: Immobilized Candida antarctica lipase B (CALB)-catalyzed polycondensation of glycerol and sebacic acid at mild reaction conditions resulted in branched poly(glycerol sebacate) (PGS). To understand how PGS chains grow and branch, the kinetics of the CALB-catalyzed polycondensation were studied. The influence of the reaction temperature, solvent, CALB amount, and sebacic acid/glycerol feed ratio on the poly(glycerol sebacate) (PGS) molecular weight, degree of branching, and glyceridic repetitive unit distribution was also investigated. PGS architecture changes from linear to branched with the progression of the reaction, and the branching results from the simultaneous CALB-catalyzed esterification and acyl migration. For reactions performed in acetone at the temperature range from 30 to 50 °C, the apparent rate constant increases from 0.7 to 1.5 h–1, and the apparent energy of activation of 32 kJ mol–1 was estimated. The higher mass average molecular weight (16 kDa) and degree of branching (41%) were achieved using the equimolar sebacic acid/glycerol feed ratio in acetone at 40 °C with a CALB amount of 13.6 wt % and in the presence of the molecular sieves
Subject: Enzimas
Cinetica de enzimas
Country: Estados Unidos
Editor: American Chemical Society
Rights: Fechado
Identifier DOI: 10.1021/acs.macromol.0c01709
Address: https://pubs.acs.org/doi/10.1021/acs.macromol.0c01709
Date Issue: 2020
Appears in Collections:IQ - Artigos e Outros Documentos

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