Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/348390
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCunha, Lucas Leite-
dc.contributor.authorunicampVassallo, José-
dc.contributor.authorunicampWard, Laura Sterian-
dc.typeArtigopt_BR
dc.titleFoxp3 expression is associated with aggressiveness in differentiated thyroid carcinomaspt_BR
dc.contributor.authorCunha, Lucas Leite-
dc.contributor.authorMorari, Elaine Cristina-
dc.contributor.authorSuely, Nonogaki-
dc.contributor.authorSoares, Fernando Augusto-
dc.contributor.authorVassallo, José-
dc.contributor.authorWard, Laura Sterian-
dc.subjectLinfócitos T reguladorespt_BR
dc.subjectCarcinoma da glândula tireoide não medularpt_BR
dc.subject.otherlanguageT-Lymphocytes, regulatorypt_BR
dc.subject.otherlanguageThyroid Carcinoma, Nonmedullary 1pt_BR
dc.description.abstractForkhead box P3 (FoxP3) expression has been observed in human cancer cells but has not yet been reported in thyroid cells. We investigated the prognostic significance of both FoxP3 expression and intratumoral FoxP3+ lymphocyte infiltration in differentiated thyroid carcinoma cells. We constructed a tissue microarray with 385 thyroid tissues, including 266 malignant tissues (from 253 papillary thyroid carcinomas and 13 follicular carcinomas), 114 benign lesions, and 5 normal thyroid tissues. We determined the expression of FoxP3 in both tumor cells and tumor-infiltrating lymphocytes using immunohistochemical techniques. Cellular expression of FoxP3 was evident in 71% of benign and 91.9% of malignant tissues. The nuclear and cytoplasmic expression patterns were quantified separately. A multivariate logistic regression analysis indicated that cytoplasmic FoxP3 expression is an independent risk factor for thyroid malignancy. Cytoplasmic FoxP3 staining was inversely correlated with patient age. Nuclear FoxP3 staining was more intense in younger patients and in tumors presenting with metastasis at diagnosis. FoxP3+ lymphocytes were more frequent in tumors smaller than 2 cm, those without extrathyroidal invasion, and in patients with concurrent chronic lymphocytic thyroiditis. We demonstrated FoxP3 expression in differentiated thyroid carcinoma cells and found evidence that this expression may exert an important influence on several features of tumor aggressivenesspt_BR
dc.relation.ispartofClinicspt_BR
dc.relation.ispartofabbreviationClinics (São Paulo)pt_BR
dc.publisher.citySão Paulo, SPpt_BR
dc.publisher.countryBrasilpt_BR
dc.publisherUSPpt_BR
dc.date.issued2012-
dc.language.isoengpt_BR
dc.description.volume67pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage483pt_BR
dc.description.lastpage488pt_BR
dc.rightsAbertopt_BR
dc.sourceSciELOpt_BR
dc.identifier.issn1807-5932pt_BR
dc.identifier.eissn1980-5322pt_BR
dc.identifier.doi10.6061/clinics/2012(05)13pt_BR
dc.identifier.urlhttps://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000500013pt_BR
dc.date.available2020-08-31T19:39:23Z-
dc.date.accessioned2020-08-31T19:39:23Z-
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dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/348390-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Anatomia Patológicapt_BR
dc.contributor.departmentDepartamento de Clínica Médicapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.identifier.sourceS1807-59322012000500013pt_BR
dc.creator.orcid0000-0002-1513-1455pt_BR
dc.creator.orcid0000-0002-2192-4865pt_BR
dc.creator.orcidsem informaçãopt_BR
dc.type.formArtigopt_BR
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