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Type: Artigo
Title: Response surface optimization of phenolic compounds from jabuticaba (myrciaria cauliflora [mart.] o.berg) seeds: antioxidant, antimicrobial, antihyperglycemic, antihypertensive and cytotoxic assessments
Author: Fidelis, Marina
Carmo, Mariana Araújo Vieira do
Azevedo, Luciana
Cruz, Thiago Mendanha
Marques, Mariza Boscacci
Myoda, Takao
Sant’Ana, Anderson S.
Furtado, Marianna Miranda
Wen, Mingchun
Zhang, Liang
Rosso, Neiva Deliberali
Genovese, Maria Inês
Oh, Won Young
Shahidi, Fereidoon
Pap, Nora
Granato, Daniel
Abstract: The aim of this study was to evaluate the effects of different solvents and maximize the extraction of bioactive compounds from jabuticaba (Myrciaria cauliflora) seeds. In general, the solvent system composed of water and propanone (52:48 v/v) modified the extract polarity and increased extraction yield of bioactive compounds. The optimized extract presented antioxidant capacity measured by different chemical and biological assays. The optimized extract exerted antiproliferative and cytotoxic effects against A549 and HCT8 cells, antimicrobial and antihemolytic effects, inhibited α-amylase/α-glucosidase activities and presented in vitro antihypertensive effect. Nonetheless, the optimized extract showed no cytotoxicity in a human cell model (IMR90). Vescalagin, castalagin and ellagic acid were the major phenolic compounds in the optimized extract. Our results show that jabuticaba seed may be a potential ingredient for the development of potentially functional foods
Subject: Bioatividade
Country: Reino Unido
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.fct.2020.111439
Date Issue: 2020
Appears in Collections:FEA - Artigos e Outros Documentos

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