Use este identificador para citar ou linkar para este item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/344637
Tipo: Artigo
Título: Bromelain loading and release from a hydrogel formulated using alginate and arabic gum
Autor(es): Ataide, Janaína Artem
Cefali, Letícia Caramori
Rebelo, Marcia de Araujo
Spir, Lívia Genovez
Tambourgi, Elias Basile
Jozala, Angela Faustino
Chaud, Marco Vinícius
Silveira, Edgar
Gu, Xiaochen
Mazzola, Priscila Gava
Resumo: An ideal wound dressing ensures a moist environment around the wound area and absorbs exudates from the wound surface. Topical application of bromelain to incised wounds has been shown to reprogram the wound microenvironment to promote effective tissue repair. Combining the characteristics of hydrogels and bromelain is therefore of great interest. Herein, we describe the development of a hydrogel, formulated using alginate and Arabic gum, for bromelain loading and release. The hydrogel formulation was evaluated using response surface methodology, considering the pH value and the concentration of alginate and Arabic gum. Bromelain loading and release were evaluated based on passive diffusion. Differential scanning calorimetry and Fourier transform infrared spectroscopy were performed to confirm bromelain immobilization in the hydrogel. The final hydrogel formulation had a swelling ratio of 227 % and incorporated 19 % of bromelain from a bromelain solution. Bromelain immobilization in the hydrogel was the result of hydrogen bond formation and was optimal at 4 °C after 4 h of contact. This evidence suggests that bromelain entrapment into a hydrogel is a promising strategy for the development of wound dressings that support the debridement of burns and wounds
Palavras-chave: Hidrogéis
País: Alemanha
Editor: Georg Thieme Verlag
Tipo de Acesso: Aberto
Identificador DOI: 10.1055/s-0043-102948
Endereço : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0043-102948
Data do documento: 2017
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