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Type: Artigo
Title: IL8 and IL17A polymorphisms associated with multibacillary leprosy and reaction type 1 in a mixed population from southern Brazil
Author: Aquino, Julimary Suematsu
Ambrosio‐Albuquerque, Eliane Papa
Alves, Hugo Vicentin
Macedo, Luciana Conci
Visentainer, Lorena
Sell, Ana Maria
Visentainer, Jeane Eliete Laguila
Abstract: We evaluated the influence of the IL8 T‐738A (nonidentified rs), IL8 T‐353A (rs4073), IL17A G197A (rs2275913), and IL17F T7488C (rs763780) single‐nucleotide polymorphisms on leprosy. The AA genotype of IL8 T‐353A was observed as a risk factor for multibacillary leprosy, regardless of gender and age‐of‐onset of disease, considering the recessive model (OR, 3.8; 95% CI, 1.1–13.5; P, 0.023). Furthermore, the AA genotype of IL17A G197A was associated with leprosy type 1 reaction (OR, 2.4; 95% CI, 1.1–5.1; P, 0.026) when compared to the group without reaction, which was adjusted for gender and age‐of‐onset of disease by the model log additive. These results indicate association of IL8 and IL17A polymorphisms with the progression to multibacillary leprosy and with the type 1 reaction, respectively
Subject: Interleucina-17
Polimorfismo (Genética)
Country: Reino Unido
Editor: Wiley
Rights: Fechado
Identifier DOI: 10.1111/ahg.12291
Date Issue: Mar-2019
Appears in Collections:FCM - Artigos e Outros Documentos

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