Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/338878
Type: Artigo
Title: Crystal structure, anti-trypanosoma cruzi and cytotoxic activities of Cu(II) complexes bearing beta-diketone and alpha-diimine ligands
Author: Paixao, Drielly A.
de Oliveira, Barbara C. A.
Almeida, Janaina do Couto
Sousa, Luana M.
Lopes, Carla D.
Carneiro, Zumira A.
Tezuka, Daiane Y.
Clavijo, Juan Carlos T.
Ellena, Javier
Polloni, Lorena
Machado, Pedro H. A.
de Albuquerque, Sergio
de Oliveira Junior, Robson J.
Guilardi, Silvana
Guerra, Wendell
Abstract: Three novel copper(II) complexes were synthesized: [Cu(tfa)(2)] (I), [Cu(tfa)(dmb)(NO3)]center dot 1.5H(2)O (II) and [Cu(tfa)(nphen)(NO3)] (III), where tfa = 4,4,4-trifluoro-1-(2-furyl)-1,3-butanedione, nphen = 5-nitro-1,10-phenanthroline and dmb = 4,4-dimethoxy-2,2-bipyridine. They were characterized by elemental analysis, conductivity measurements, FT-IR, UV-Vis and single-crystal X-ray diffraction. The X-ray crystal structures of I, II and III reveal that the beta-diketone coordinates via the oxygen atoms, while the heterocyclic bases coordinate via their two nitrogen atoms. The cytotoxic activity of I, II and III was investigated in two tumor cell lines (Ehrlich tumor and sarcoma 180) and in a non-tumor cell line (myoblast C2C12). Complex DI exhibited good activity (IC50 (Ehrlich) = 15.75 mu M and IC50 (sarcoma )180 = 16.90 mu M) and selectivity (SI > 4) in both tumor cell lines. Subsequently, it was found that III also present good activity against Trypanosoma cruzi
Subject: Câncer
Country: Países Baixos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.ica.2019.119164
Address: https://www.sciencedirect.com/science/article/pii/S0020169319308886
Date Issue: 2020
Appears in Collections:IQ - Artigos e Outros Documentos

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