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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampReis, Sabrina Karen-
dc.contributor.authorunicampSocca, Eduardo Augusto Rabelo-
dc.contributor.authorunicampFávaro, Wagner José-
dc.typeArtigopt_BR
dc.titleProbiotic supplementation attenuates the aggressiveness of chemically induced colorectal tumor in ratspt_BR
dc.contributor.authorGenaro, Sandra Cristina-
dc.contributor.authorReis, Luis Souza Lima de Souza-
dc.contributor.authorReis, Sabrina Karen-
dc.contributor.authorSocca, Eduardo Augusto Rabelo-
dc.contributor.authorFávaro, Wagner José-
dc.subjectNeoplasias colorretaispt_BR
dc.subjectAlimentos funcionaispt_BR
dc.subjectQuimioterapiapt_BR
dc.subject.otherlanguageColorectal neoplasmspt_BR
dc.subject.otherlanguageFunctional foodspt_BR
dc.subject.otherlanguageChemotherapypt_BR
dc.description.abstractTo evaluate the effect of a probiotic on the aggressiveness of a chemically induced colorectal tumor in rats. Twenty-five male Fisher 344 rats, 250 g, provided with feed and water ad libitum, were randomly divided into 5 groups (5 rats/group): GControl, no treatment; GTumor, tumor induction; GTumor+5FU, tumor induction, 5-Fluorouracil applied; GTumor+Prob, induction of the tumor, supplemented with probiotic; GTumor+5-FU+Prob, tumor induction, 5-Fluorouracil applied, supplemented with probiotic. For tumor induction 20 mg/kg of 1,2-dimethylhydrazine was applied intraperitoneally over 4 weeks, followed by an interval of 15 days, and then repeated for a further 4 weeks. Five weeks after the final dose of the carcinogen, treatment was initiated with 5-Fluorouracil (15 mg/kg, intraperitoneally/week) and a commercial probiotic (1 × 109 CFU, daily/gavage). Data were analyzed by One Way Variance Analysis and means compared by Dunnett's test. GraphPad Prism statistical software was used. The histopathological analyzes were evaluated by the chi-square test. A 5% type-I error was considered statistically significant. Compared with the GTumor, the GTumor+Prob (p < 0.0373) and GTumor+5-FU+Prob (p < 0.0003) demonstrated an attenuated effect on the aggressiveness of the colorectal tumor, with a reduction in the count of Aberrant Crypt foci; and a lower percentage of malignant neoplastic lesions in the GTumor+Prob (40% low grade tubular adenoma, 40% carcinoma in situ, 20% low grade adenocarcinoma) and GTumor+5-FU+Prob (40% low grade tubular adenoma and 60% carcinoma in situ). Probiotic supplementation has the potential to decrease the formation of aberrant crypts and ameliorate tumor malignancy, enhancing the antitumor effect of 5-Fluorouracil chemotherapy in colic segmentspt_BR
dc.relation.ispartofLife sciencespt_BR
dc.relation.ispartofabbreviationLife scipt_BR
dc.publisher.cityEstados Unidospt_BR
dc.publisher.countryPhiladelphia, PApt_BR
dc.publisherElsevierpt_BR
dc.date.issued2019-11-
dc.date.monthofcirculationNov.pt_BR
dc.language.isoengpt_BR
dc.description.volume237pt_BR
dc.rightsFechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0024-3205pt_BR
dc.identifier.eissn1879-0631pt_BR
dc.identifier.doi10.1016/j.lfs.2019.116895pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0024320519308227#!pt_BR
dc.date.available2020-04-08T20:23:53Z-
dc.date.accessioned2020-04-08T20:23:53Z-
dc.description.provenanceSubmitted by Susilene Barbosa da Silva (susilene@unicamp.br) on 2020-04-08T20:23:53Z No. of bitstreams: 0. Added 1 bitstream(s) on 2020-07-30T19:33:29Z : No. of bitstreams: 1 000498674800022.pdf: 2944104 bytes, checksum: 4dba76d7c144585b84ac9252a553a5b0 (MD5)en
dc.description.provenanceMade available in DSpace on 2020-04-08T20:23:53Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-11en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/338821-
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentSem informaçãopt_BR
dc.contributor.departmentDepartamento de Biologia Estrutural e Funcionalpt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Ciências Médicaspt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.subject.keywordAberrant crypt focipt_BR
dc.subject.keywordIntestinal microbitapt_BR
dc.identifier.source000498674800022pt_BR
dc.creator.orcid0000-0003-3967-0792pt_BR
dc.creator.orcidSem informaçãopt_BR
dc.creator.orcid0000-0001-5830-8938pt_BR
dc.type.formArtigopt_BR
dc.identifier.articleid116895pt_BR
dc.description.sponsorNoteThe authors would like to thank the NANOBIOSS/UNICAMP Laboratories, INOMAT/UNICAMP, the NANOREG-MCTIC Program, and the Surgery Science Program/UNICAMP and University of Western São Paulo for financial support and research viabilitypt_BR
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FCM - Artigos e Outros Documentos

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