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Type: Artigo
Title: Unsaturated fatty acids from flaxseed oil and exercise modulate GPR120 but not GPR40 in the liver of obese mice: a new anti-inflammatory approach
Author: Gaspar, Rafael Calais
Veiga, Camilla Bertuzzo
Bessi, Mariana Pereira
Datilo, Marcella Neves
Sant'Ana, Marcella Ramos
Rodrigues, Patricia Brito
Moura, Leandro Pereira de
Silva, Adelino Sanchez Ramos da
Santos, Gustavo Aparecido
Catharino, Rodrigo Ramos
Ropelle, Eduardo Rochete
Pauli, Jose Rodrigo
Cintra, Dennys Esper
Abstract: GPR120 and GPR40 were recently reported as omega-3 (omega 3) receptors with anti-inflammatory properties. Physical exercise could increase the expression of these receptors in the liver, improving hepatic metabolism in obesity and type 2 diabetes. Our aim was to investigate GPR120/40 in the liver of lean and obese mice after acute or chronic physical exercise, with or without the supplementation of omega 3 rich flaxseed oil (FS), as well as assess the impact of exercise and FS on insulin signaling and inflammation. Mice were fed a high-fat diet (HF) for 4 weeks to induce obesity and subsequently subjected to exercise with or without FS, or FS alone. Insulin signaling, inflammatory markers and GPR120/40 and related cascades were measured. Chronic, but not acute, exercise and FS increased GPR120, but not GPR40, activating beta-arrestin-2 and decreasing the inflammatory response, as well as reducing fat depots in liver and adipose tissue. Exercise or a source of omega 3 led to a higher tolerance to fatigue and an increased running distance and speed. The combination of physical exercise and omega 3 food sources could provide a new strategy against obesity through the modulation of hepatic GPR120 and an increase in exercise performance
Subject: Obesidade
Ácidos graxos insaturados
Exercícios físicos
Country: Estados Unidos
Editor: Elsevier
Rights: Fechado
Identifier DOI: 10.1016/j.jnutbio.2018.12.003
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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