Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/336197
Type: Artigo
Title: Technetium-99m-dimercaptosuccinic acid renal scintigraphy and single photon emission computed tomography/computed tomography in patients with sickle cell disease
Author: Ramos, Celso Dario
Onusic, Daniel Massaro
Brunetto, Sergio Querino
Amorim, Barbara Juarez
Souza, Thiago Ferreira
Olalla Saad, Sara Teresinha
Lopes Lima, Mariana da Cunha
Abstract: Purpose Sickle cell disease (SCD) is a common hematologic hereditary disorder characterized by vaso-occlusive episodes affecting multiple organs, and substantially alters renal structure and function. We aimed to evaluate the utility of renal scintigraphy and single photon emission computed tomography/computed tomography (SPECT/CT) with technetium-99m-dimercaptosuccinic acid (Tc-99m-DMSA) in adult patients with SCD and no clinical evidence of renal insufficiency. Materials and methods Twenty-six patients (16 female) aged 23-58 years with SCD and no clinical evidence of renal insufficiency were prospectively studied. Planar and SPECT/CT images were, respectively, obtained after 3 and 4 hours of the injection of 110-180 MBq of Tc-99m-DMSA. The relative radiopharmaceutical uptake and renal length were, respectively, determined using SPECT and CT images. Planar and SPECT/CT images were visually analyzed to identify focal areas of Tc-99m-DMSA reduced uptake and anatomical deformities of the kidneys. Results Focal areas of reduced Tc-99m-DMSA uptake with an image aspect of renal scars or inflammation were present in 21/26 patients (81%). In 11/21 (52%) of these patients, the cortical lesions were clearly identified only on SPECT images. Prominent renal columns were observed in 17/26 (65%) patients. The left kidney tended to be more affected than the right kidney. Most patients had enlarged kidneys. Conclusion Tc-99m-DMSA scintigraphy and SPECT/CT identify renal lesions possible related to renal infarcts or infections in most adult patients with SCD and no clinical evidence of renal insufficiency. Prominent renal columns and increased renal size tend to occur in most of these patients
Subject: Ácido dimercaptossuccínico tecnécio Tc 99m
Country: Estados Unidos
Editor: Lippincott Williams & Wilkins
Rights: fechado
Identifier DOI: 10.1097/MNM.0000000000001086
Address: https://journals.lww.com/nuclearmedicinecomm/Abstract/2019/11000/Technetium_99m_dimercaptosuccinic_acid_renal.10.aspx
Date Issue: 2019
Appears in Collections:FCM - Artigos e Outros Documentos
HC - Artigos e Outros Documentos
CEB - Artigos e Outros Documentos

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