Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328951
Type: Artigo
Title: Histomorphometric Characterization Of Subgemmal Neurogenous Plaques
Histomorphometric characterization of subgemmal neurogenous plaques
Author: Amorim Pellicioli, Ana Carolina
Fonseca, Felipe Paiva
Silva, Rodrigo Neves
Monteiro Gueiros, Luiz Alcino
de Almeida, Oslei Paes
Vargas, Pablo Agustin
Lopes, Marcio Ajudarte
Rebelo Pontes, Helder Antonio
Martins, Manoela Domingues
Carrard, Vincius Coelho
Santos-Silva, Alan Roger
Abstract: The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. Study Design. A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosine stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. Results. Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm 2, and the mean distance to the overlying epithelium was 0.312 mm. Conclusions. SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions.
The aim of this study was to characterize the histomorphometric features of subgemmal neurogenous plaques (SNPs) to better understand their relationship to surrounding microanatomy included in the tissue biopsy samples of the tongue. Study Design. A 12-year retrospective study on the files of 3 oral pathology centers yielded 28 SNPs. Hematoxylin and eosine stained sections were used for histologic analysis, and immunohistochemical staining for S100 protein was performed to better characterize the neural structures. Slides were scanned and histomorphometric analysis carried out using ImageScope software. Twenty-one women (75%) and 6 men (21.4%) comprised the sample (mean age 46.4 and 49 years, respectively). Twenty cases (71.4%) were juxtaposed to the tongue epithelium and 16 cases (57.1%) were associated with lymphoid tissue. The mean area of the SNPs was 0.160 mm 2, and the mean distance to the overlying epithelium was 0.312 mm. Conclusions. SNPs are normal neural structures located on the posterior border of the tongue that represent a non-neoplastic regional anatomic variation. In some cases, signs or symptoms may be present, and further investigation should be performed. Pathologists should be aware of this entity to avoid confusion with neural lesions
Subject: Subepithelial Nerve Plexus
Juxtaoral Organ
Taste-buds
Chievitz
Tongue
Língua
Patologia bucal
Editor: Elsevier Science Inc
New York
Citation: Oral Surgery Oral Medicine Oral Pathology Oral Radiology. Elsevier Science Inc, v. 123, p. 477 - 481, 2017.
Rights: fechado
Identifier DOI: 10.1016/j.oooo.2016.12.014
Address: https://www.sciencedirect.com/science/article/pii/S2212440317300019?via%3Dihub
Date Issue: 2017
Appears in Collections:FOP - Artigos e Outros Documentos

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