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Type: Artigo
Title: The Use Of Green Tea Polyphenols For Treating Residual Albuminuria In Diabetic Nephropathy: A Double-blind Randomised Clinical Trial
Author: Borges
Cynthia M.; Papadimitriou
Alexandros; Duarte
Diego A.; de Faria
Jacqueline M. Lopes; de Faria
Jose B. Lopes
Abstract: Prior research has shown that in experimental diabetes mellitus, green tea reduces albuminuria by decreasing podocyte apoptosis through activation of the WNT pathway. We investigated the effect of green tea polyphenols (GTP) on residual albuminuria of diabetic subjects with nephropathy. We conducted a randomised, double-blind study in 42 diabetic subjects with a urinary albumin-creatinine ratio (UACR) > 30 mg/g, despite administration of the maximum recommended dose of renin-angiotensin (RAS) inhibition. Patients were randomly assigned to two equal groups to receive either GTP (containing 800 mg of epigallocatechin gallate, 17 with type 2 diabetes and 4 with type 1 diabetes) or placebo (21 with type 2 diabetes) for 12 weeks. Treatment with GTP reduced UACR by 41%, while the placebo group saw a 2% increase in UACR (p = 0.019). Podocyte apoptosis (p = 0.001) and in vitro albumin permeability (p < 0.001) were higher in immortalized human podocytes exposed to plasma from diabetic subjects compared to podocytes treated with plasma from normal individuals. In conclusion, GTP administration reduces albuminuria in diabetic patients receiving the maximum recommended dose of RAS. Reduction in podocyte apoptosis by activation of the WNT pathway may have contributed to this effect.
Subject: Kidney-disease
Editor: Nature Publishing Group
Citation: Scientific Reports. Nature Publishing Group, v. 6, p. , 2016.
Rights: aberto
Identifier DOI: 10.1038/srep28282
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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